TRPM2

Description		transient receptor potential cation channel subfamily M member 2
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Intracellularly Gated Calcium Channel Activity Hydrolase Activity Metal Ion Binding Metal Ion Transmembrane Transporter Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	Temperature Homeostasis Dendritic Cell Chemotaxis Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Manganese Ion Transport Response To Heat Response To Purine-containing Compound Calcium-mediated Signaling Regulation Of Actin Cytoskeleton Organization Response To Hydroperoxide Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane
Pathways		TRP channels Neutrophil degranulation
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Novel Interacting Genes		1 novel interacting genes: TRAPPC10
Interacting Genes		3 interacting genes: EFHC1 ITPR3 TRPC6
Entrez ID		7226
HPRD ID		04777
Ensembl ID		ENSG00000142185
Uniprot IDs		B4DVI8 E9PGK7 O94759 Q14DR2
PDB IDs		6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU 7VQ1 7VQ2 8E6Q 8E6R 8E6S 8E6T 8E6U 8E6V
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Inositol 1,3,4,5 Tetrakisphosphate Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Umami Taste Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Sensory Perception Of Sweet Taste Monoatomic Ion Channel Activity Calcium Ion Homeostasis Sensory Perception Of Bitter Taste Calcium Ion Transport Calcium Ion Transmembrane Transport Inositol Hexakisphosphate Binding Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Slit Diaphragm Store-operated Calcium Channel Activity Neuronal Cell Body TRAPPII Protein Complex Inorganic Ion Homeostasis TRAPP Complex Actinin Binding Cytoplasmic Side Of Endoplasmic Reticulum Membrane Early Endosome To Golgi Transport Cation Channel Complex Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Axonemal A Tubule Inner Sheath Sensory Perception Of Taste Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Nuclear Outer Membrane Calcium Ion Binding Intra-Golgi Vesicle-mediated Transport Vesicle Tethering Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Axonemal Microtubule Cerebral Cortex Cell Migration Vesicle Coating
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