STOM and PTCH1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STOM	PTCH1
Description		stomatin	patched 1
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle	Golgi Apparatus Plasma Membrane Caveola Cilium Membrane Midbody Endocytic Vesicle Membrane Dendritic Growth Cone Axonal Growth Cone Apical Part Of Cell Postsynaptic Membrane Perinuclear Region Of Cytoplasm Ciliary Membrane
	Molecular Function	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding
	Biological Process	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Formation Neural Tube Closure Heart Morphogenesis Signal Transduction Spermatid Development Regulation Of Mitotic Cell Cycle Pattern Specification Process Brain Development Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Xenobiotic Stimulus Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Dorsal/ventral Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Mammary Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Response To Alkaloid Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Smooth Muscle Tissue Development Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Stem Cell Proliferation Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration Negative Regulation Of Stem Cell Proliferation
Pathways		Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle	Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO
Drugs
Diseases		Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)	Holoprosencephaly (HPE) Basal cell carcinoma Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Alanine aminotransferase levels ( 33547301) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 28869591 30598549) Height ( 25429064 28552196 31562340 18391952 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)
Interacting Genes		81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6	21 interacting genes: APPBP2 ATG101 ATM CCNB1 CD200R1 CD74 CD79A CDK1 CREB3 DHH FAM209A HIBADH HIPK2 IHH SHH SIGLEC12 SMO STOM TMPRSS2 TSPAN8 YAP1
Entrez ID		2040	5727
HPRD ID		00585	03200
Ensembl ID		ENSG00000148175	ENSG00000185920
Uniprot IDs		F8VSL7 P27105	A0A0C4DGJ5 A0A1W5YLI7 Q13635
PDB IDs		7WH3	6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane	Patched Binding Cholesterol-protein Transferase Activity Protein Autoprocessing Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Self Proteolysis Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Somite Development Cyclin B1-CDK1 Complex Intein-mediated Protein Splicing Embryonic Heart Tube Morphogenesis Smooth Muscle Tissue Development Cell Fate Specification Developmental Growth Cell Development Regulation Of Organ Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Epithelial Tube Morphogenesis Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Positive Regulation Of Protein Import Into Nucleus Epithelial-mesenchymal Cell Signaling Cell Population Proliferation Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Anterior/posterior Pattern Specification Positive Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Lymphocyte Activation Regulation Of Growth Ventricular Cardiac Muscle Cell Development Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of T Cell Differentiation In Thymus
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