STOM and ASIC3

Number of citations of the paper that reports this interaction (PubMedID 15471860)
0

Data Source:
HPRD (in vivo)

		STOM	ASIC3
Description		stomatin	acid sensing ion channel subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding	Monoatomic Cation Channel Activity Sodium Channel Activity Ligand-gated Sodium Channel Activity Enterobactin Transmembrane Transporter Activity PH-gated Sodium Channel Activity PH-gated Monoatomic Ion Channel Activity
	Biological Process	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Response To Heat Response To Mechanical Stimulus Response To Acidic PH Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Enterobactin Transport Detection Of Chemical Stimulus Involved In Sensory Perception Sensory Perception Of Sour Taste Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Membrane Depolarization
Pathways		Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle	Stimuli-sensing channels
Drugs			Agmatine
Diseases		Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS			Eyebrow thickness ( 26926045)
Interacting Genes		81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6	9 interacting genes: ASIC2 CSNK2A1 DLG4 GOPC LIN7B MAGI1 PATJ PRKACA STOM
Entrez ID		2040	9311
HPRD ID		00585	10626
Ensembl ID		ENSG00000148175	ENSG00000213199
Uniprot IDs		F8VSL7 P27105	A0A090N7X8 A0A090N8Q1 A0A090N8Z6 Q9UHC3
PDB IDs		7WH3
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane	Regulation Of Monoatomic Ion Transmembrane Transport Plasma Membrane Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Bicellular Tight Junction Intracellular Protein Localization Cell Junction Establishment Of Protein Localization Regulation Of Cell Junction Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Cellular Component Assembly Establishment Of Localization In Cell P2Y1 Nucleotide Receptor Binding Negative Regulation Of Anion Channel Activity Regulation Of Transport Neuromuscular Junction Protein Localization To Cell Junction Synapse PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Anchoring Junction Cell Periphery Protein Kinase CK2 Complex Protein Transport Symbiont-mediated Disruption Of Host Cell PML Body Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Dendritic Spine Regulation Of System Process Positive Regulation Of Aggrephagy AMPA Glutamate Receptor Clustering Cell Projection Neuroligin Family Protein Binding MPP7-DLG1-LIN7 Complex Regulation Of Synapse Assembly NMDA Selective Glutamate Receptor Signaling Pathway Establishment Or Maintenance Of Cell Polarity CAMP-dependent Protein Kinase Activity
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