MAST2 and SLC9A3

Number of citations of the paper that reports this interaction (PMID 16159897)
6

Data Source:
HPRD (in vitro, in vivo)

		MAST2	SLC9A3
Gene Name		microtubule associated serine/threonine kinase 2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Microtubule Cytoskeleton	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Phosphatase Binding	Protein Binding Sodium:proton Antiporter Activity PDZ Domain Binding
	Biological Process	Protein Phosphorylation Regulation Of Interleukin-12 Biosynthetic Process Spermatid Differentiation	Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways			Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS			Ulcerative colitis ( 23128233)
Protein-Protein Interactions		15 interactors: APP CDHR2 DYNLL1 PTEN RPS27A SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 STK36 SUMO2 TK1 TRAF2 TRAF6	8 interactors: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2
Entrez ID		23139	6550
HPRD ID		11294	01660
Ensembl ID		ENSG00000086015	ENSG00000066230
Uniprot IDs		Q6P0Q8	P48764
PDB IDs		2KQF 2KYL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Component Assembly I-kappaB Kinase/NF-kappaB Signaling Neurotrophin TRK Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Apoptotic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Programmed Cell Death Toll-like Receptor 4 Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Apoptotic Process Cell Death Positive Regulation Of Programmed Cell Death Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Cell Death Antigen Processing And Presentation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Proteolysis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Positive Regulation Of T Cell Cytokine Production Regulation Of Phosphorylation Pattern Recognition Receptor Signaling Pathway Regulation Of Kinase Activity Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Immune System Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of T Cell Cytokine Production	Regulation Of Sodium:proton Antiporter Activity Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Proton Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Intracellular Protein Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Renal Phosphate Ion Absorption Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatase Activity Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of Dephosphorylation Monocarboxylic Acid Transport Regulation Of Protein Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Regulation Of Signaling Renal Sodium Ion Transport Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Ion Transport Cellular Component Assembly Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Sodium Ion Transmembrane Transport Protein Localization
Tagcloud ?			1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Difference) ?			1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Intersection) ?