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MAST2 and PTEN
Number of citations of the paper that reports this interaction (PMID
15951562
)
36
Data Source:
HPRD
(in vitro, two hybrid)
MAST2
PTEN
Gene Name
microtubule associated serine/threonine kinase 2
phosphatase and tensin homolog
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Microtubule Cytoskeleton
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
PML Body
Myelin Sheath Adaxonal Region
Cell Projection
Neuron Projection
Dendritic Spine
Schmidt-Lanterman Incisure
Postsynaptic Membrane
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Phosphatase Binding
Magnesium Ion Binding
Phosphatidylinositol-3-phosphatase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Lipid Binding
Anaphase-promoting Complex Binding
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
Enzyme Binding
Protein Kinase Binding
PDZ Domain Binding
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Biological Process
Protein Phosphorylation
Regulation Of Interleukin-12 Biosynthetic Process
Spermatid Differentiation
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Regulation Of B Cell Apoptotic Process
Protein Dephosphorylation
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Apoptotic Process
Activation Of APC-Cdc20 Complex Activity
Epidermal Growth Factor Receptor Signaling Pathway
Neuron-neuron Synaptic Transmission
Synapse Assembly
Central Nervous System Development
Heart Development
Aging
Response To Nutrient
Learning Or Memory
Memory
Locomotory Behavior
Cell Proliferation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Glucose
Response To Zinc Ion
Regulation Of Neuron Projection Development
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Dentate Gyrus Development
Central Nervous System Neuron Axonogenesis
Negative Regulation Of Cell Migration
Negative Regulation Of Myelination
Regulation Of Protein Stability
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
Central Nervous System Myelin Maintenance
Response To Estradiol
Regulation Of Cellular Component Size
Regulation Of Myeloid Cell Apoptotic Process
Response To ATP
Multicellular Organismal Response To Stress
Social Behavior
Peptidyl-tyrosine Dephosphorylation
Fc-epsilon Receptor Signaling Pathway
Response To Drug
Maternal Behavior
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
Response To Ethanol
Locomotor Rhythm
Negative Regulation Of Cell Size
Negative Regulation Of Organ Growth
Response To Arsenic-containing Substance
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Cardiac Muscle Tissue Development
Forebrain Morphogenesis
Brain Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Phagocytosis
Negative Regulation Of Axonogenesis
Protein Stabilization
T Cell Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Focal Adhesion Assembly
Negative Regulation Of Protein Kinase B Signaling
Rhythmic Synaptic Transmission
Canonical Wnt Signaling Pathway
Synapse Maturation
Prepulse Inhibition
Male Mating Behavior
Long-term Synaptic Potentiation
Long Term Synaptic Depression
Prostate Gland Growth
Dendritic Spine Morphogenesis
Negative Regulation Of Dendritic Spine Morphogenesis
Negative Regulation Of Ribosome Biogenesis
Negative Regulation Of Cell Aging
Negative Regulation Of Excitatory Postsynaptic Membrane Potential
Presynaptic Membrane Assembly
Postsynaptic Density Assembly
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Negative Regulation Of Synaptic Vesicle Clustering
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Downstream TCR signaling
Metabolism of lipids and lipoproteins
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Synthesis of PIPs at the plasma membrane
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
PI3K/AKT activation
Synthesis of IP3 and IP4 in the cytosol
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Phospholipid metabolism
PI Metabolism
Innate Immune System
Signaling by PDGF
DAP12 interactions
Signalling by NGF
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Negative regulation of the PI3K/AKT network
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Inositol phosphate metabolism
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
TCR signaling
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
APP
CDHR2
DYNLL1
PTEN
RPS27A
SH3GL2
SLC34A1
SLC9A3
SMN1
SNTB2
STK36
SUMO2
TK1
TRAF2
TRAF6
34 interactors:
AKT1
ANG
AR
CAV1
CDC27
CHGB
COPS6
CSNK2A1
CSNK2A2
DLG1
ESR1
FZR1
HBA1
LATS1
MAGI2
MAGI3
MAST1
MAST2
MAST3
MVP
NDFIP1
NEDD4
PARK7
PPP1CA
PXN
SLC9A3R1
SLC9A3R2
STK11
TP53
UBE2I
UBE2L3
USP13
UTP14A
WWP1
Entrez ID
23139
5728
HPRD ID
11294
03431
Ensembl ID
ENSG00000086015
Uniprot IDs
Q6P0Q8
F6KD01
P60484
PDB IDs
2KQF
2KYL
1D5R
2KYL
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Proteolysis
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Cellular Component Assembly
I-kappaB Kinase/NF-kappaB Signaling
Neurotrophin TRK Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Neurotrophin Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen
Apoptotic Process
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Programmed Cell Death
Toll-like Receptor 4 Signaling Pathway
Regulation Of ERBB Signaling Pathway
Positive Regulation Of Apoptotic Process
Cell Death
Positive Regulation Of Programmed Cell Death
Death
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Cell Death
Antigen Processing And Presentation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Immunoglobulin Secretion
Regulation Of Proteolysis
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Toll-like Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Signal Transduction
Positive Regulation Of T Cell Cytokine Production
Regulation Of Phosphorylation
Pattern Recognition Receptor Signaling Pathway
Regulation Of Kinase Activity
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Antigen Receptor-mediated Signaling Pathway
Innate Immune Response
Activation Of Innate Immune Response
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Immune System Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of T Cell Cytokine Production
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Catalytic Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transferase Activity
Negative Regulation Of Signaling
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cell Cycle Process
Negative Regulation Of Signal Transduction
Cell Cycle
Regulation Of Cellular Component Organization
Positive Regulation Of Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cellular Protein Modification Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Cellular Metabolic Process
Positive Regulation Of Phosphorylation
Mitotic Cell Cycle Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Phosphorylation
Regulation Of Cell Proliferation
Mitotic Cell Cycle
Negative Regulation Of Intracellular Signal Transduction
Protein Complex Assembly
Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Protein Catabolic Process
Protein Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Transferase Activity
Negative Regulation Of Protein Metabolic Process
Cell Communication
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Regulation Of Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Tagcloud
?
10q
already
ath
aths
atypical
bax
carcinogenesis
ec
ecs
endometrial
frequencies
hyperplasias
igfiir
instability
lead
lesions
lohs
microsatellite
msis
mutated
mutations
pathogenesis
precursor
premalignant
pursue
putative
rii
simple
tgf
Tagcloud (Difference)
?
10q
already
ath
aths
atypical
bax
carcinogenesis
ec
ecs
endometrial
frequencies
hyperplasias
igfiir
instability
lead
lesions
lohs
microsatellite
msis
mutated
mutations
pathogenesis
precursor
premalignant
pursue
putative
rii
simple
tgf
Tagcloud (Intersection)
?