HRAS and PIK3CG

Number of citations of the paper that reports this interaction (PubMedID 11136978)
0

Data Source:
HPRD (in vitro)

		HRAS	PIK3CG
Description		HRas proto-oncogene, GTPase	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Glutamatergic Synapse GTPase Complex	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-membrane Adaptor Activity Phospholipase C Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Identical Protein Binding Ephrin Receptor Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Transcription By RNA Polymerase II Endocytosis Chemotaxis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Schwann Cell Development Positive Regulation Of Cell Migration Positive Regulation Of Type II Interferon Production Regulation Of Actin Cytoskeleton Organization T-helper 1 Type Immune Response Regulation Of Cell Population Proliferation Myelination Defense Response To Protozoan Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Regulation Of Cell Cycle Adipose Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Gamma Radiation Positive Regulation Of Wound Healing Positive Regulation Of Protein Targeting To Membrane Cellular Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Ruffle Assembly Positive Regulation Of MiRNA Metabolic Process	Angiogenesis Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Endothelial Cell Migration T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Cell Migration Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Cellular Response To CAMP Neutrophil Extravasation Hepatocyte Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Fibroblast Apoptotic Process
Pathways		SOS-mediated signalling Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signaling by SCF-KIT Signalling to RAS p38MAPK events p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R FCERI mediated MAPK activation NCAM signaling for neurite out-growth EPHB-mediated forward signaling Ras activation upon Ca2+ influx through NMDA receptor VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF Insulin receptor signalling cascade PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Activated NTRK2 signals through RAS Erythropoietin activates RAS Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK3 signals through RAS FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by RAS GAP mutants Signaling by RAS GTPase mutants	GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Co-stimulation by ICOS
Drugs		Hexane-1,6-Diol Trifluoroethanol Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE Ursolic acid	Staurosporine Myricetin LY-294002 Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE Wortmannin 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Duvelisib Fostamatinib
Diseases		Penile cancer Cervical cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Hepatocellular carcinoma Thyroid cancer Squamous cell carcinoma Bladder cancer
GWAS			Antisaccade task score ( 31596458) Blood pressure ( 21909110) Carotid intima media thickness ( 21909108 30510157) Carotid plaque ( 30510157) Mean platelet volume ( 22423221 19820697 22139419 28031487 24026423) Metabolite levels ( 23823483) Platelet aggregation ( 29185836) Platelet count ( 22139419 22423221 29066854 29403010) Pulse pressure ( 29403010 30487518 26390057 28739976 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 28739976 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		148 interacting genes: ABR ACTG1 AFDN AGTR1 ANAPC1 ANKRD11 ANKRD16 ANKRD23 ANKRD34B APBB1IP ARAF ARFGAP1 ARHGAP10 ARHGAP29 ARHGEF1 ARHGEF18 BCL2 BLID BMPR1A BRAF BRAP BUB1 CAV1 CDC123 CDC25A CDC25C CDH1 CDKN2A CTNNA1 CXCL1 DEAF1 DGKE DGKZ DPP9 EIF3L ERBB2 FBXW7 FNTA FNTB FYN GPSM2 GPSM3 GRB2 GREB1 GRIN1 GRIN2D HECTD1 HSPA12A HSPA1L ICMT IKZF3 IL1RL1 IL24 IL3 INSR IRAK1 IRAK2 ITGB3 ITSN1 KRAS KRT17 KRT18 LGALS1 LZTR1 MAP2K1 MAP2K6 MAP3K6 MAPK10 MAPK8 MLH3 MSH2 MSH6 MTOR MUTYH NEDD4 NF1 NRAS PDE4D PDE6D PDGFB PDGFRL PI4K2A PIK3CA PIK3CD PIK3CG PIK3R1 PLA2G4B PLAAT4 PLCE1 PLCH2 PRKCI PRKCZ PRSS50 PTPRJ QPCT RAB5C RABAC1 RABGEF1 RAF1 RALGDS RAP1B RAP1GDS1 RAPGEF1 RASA1 RASA2 RASA4 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 RSPO3 SHOC2 SMAD4 SNRPE SNX14 SNX17 SOS1 SOS2 SRC STK11 STK38 TIAM1 TLR2 TLR6 TLR9 TP73 TTC1 TTC21A TTC28 UBE3B UBE4B USP29 USP42 VAV1 ZBTB10 ZBTB12 ZDHHC9	22 interacting genes: CD28 EPHA8 GAB1 GRB2 GRK2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PIK3R6 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		3265	5294
HPRD ID		01813	03135
Ensembl ID		ENSG00000174775	ENSG00000105851
Uniprot IDs		P01112 X5D945	A8K9G9 P48736
PDB IDs		121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2LCF 2LWI 2N42 2N46 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4L9S 4L9W 4NYI 4NYJ 4NYM 4Q21 4RSG 4URU 4URV 4URW 4URX 4URY 4URZ 4US0 4US1 4US2 4XVQ 4XVR 521P 5B2Z 5B30 5E95 5P21 5VBE 5VBZ 5WDO 5WDP 5WDQ 5WFO 5WFP 5WFQ 5WFR 5WPL 5X9S 5ZC6 621P 6AMB 6AXG 6BVI 6BVJ 6BVK 6BVL 6BVM 6CUO 6CUP 6CUR 6D55 6D56 6D59 6D5E 6D5G 6D5H 6D5J 6D5L 6D5M 6D5V 6D5W 6DZH 6E6C 6E6P 6MQT 6NTC 6NTD 6Q21 6V94 6V9F 6V9J 6V9L 6V9M 6V9N 6V9O 6ZJ0 6ZL3 721P 7DPH 7DPJ 7JHP 7JIF 7JIG 7JIH 7JII 7L0F 7L0G 7OG9 7OGA 7OGB 7OGC 7OGD 7OGE 7OGF 7TAM 7VV8 7VV9 7VVG 821P 8BE6 8BE7 8BE8 8BE9 8BEA 8BOS 8BWG 8CNJ 8CNN 8ELK 8ELR 8ELS 8ELT 8ELU 8ELV 8ELW 8ELX 8ELY 8ELZ 8EM0 8FG3 8FG4 8OSM 8OSN 8OSO 8TBG 8TLR 8WWC	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4HVB 4J6I 4KZ0 4KZC 4PS3 4PS7 4PS8 4URK 4WWN 4WWO 4WWP 4XX5 4XZ4 5EDS 5G2N 5G55 5JHA 5JHB 5KAE 5OQ4 5T23 6AUD 6C1S 6FH5 6GQ7 6T3B 6T3C 6XRL 6XRM 6XRN 7JWE 7JWZ 7JX0 7KKE 7MEZ 7Z61 8DP0 8SC8 9GG9
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cytosol Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway MAPK Cascade Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cytoplasm Positive Regulation Of MAPK Cascade Regulation Of Cell Activation Leukocyte Activation Regulation Of Cellular Component Organization Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Regulation Of Programmed Cell Death Activation Of Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune Response Regulation Of Ras Protein Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Defense Response Plasma Membrane Lymphocyte Activation	T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol 3-kinase Complex Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Phosphatidylinositol 3-kinase Complex, Class IA Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Regulation Of Cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Activation Positive Regulation Of Cell Population Proliferation Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Glial Cell Development Positive Regulation Of Gliogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Ras Protein Signal Transduction Regulation Of Multicellular Organismal Development Response To Mechanical Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Programmed Cell Death Immune System Process Plasma Membrane Cell Development Immune Response Regulation Of Gliogenesis Positive Regulation Of Gene Expression Positive Regulation Of Neurogenesis Regulated Exocytosis
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