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HRAS and BMPR1A
Number of citations of the paper that reports this interaction (PubMedID
24412244
)
0
Data Source:
BioGRID
(two hybrid)
HRAS
BMPR1A
Description
HRas proto-oncogene, GTPase
bone morphogenetic protein receptor type 1A
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
GTPase Complex
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein-membrane Adaptor Activity
Phospholipase C Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
BMP Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
BMP Receptor Activity
Biological Process
MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Endocytosis
Chemotaxis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Schwann Cell Development
Positive Regulation Of Cell Migration
Positive Regulation Of Type II Interferon Production
Regulation Of Actin Cytoskeleton Organization
T-helper 1 Type Immune Response
Regulation Of Cell Population Proliferation
Myelination
Defense Response To Protozoan
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Epithelial Cell Proliferation
T Cell Receptor Signaling Pathway
Neuron Apoptotic Process
Regulation Of Cell Cycle
Adipose Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Gamma Radiation
Positive Regulation Of Wound Healing
Positive Regulation Of Protein Targeting To Membrane
Cellular Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Positive Regulation Of Ruffle Assembly
Positive Regulation Of MiRNA Metabolic Process
Angiogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Mesoderm Formation
Somitogenesis
Mullerian Duct Regression
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Development
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Endocardial Cushion Formation
Intracellular Iron Ion Homeostasis
Immune Response
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Ectoderm Development
Nervous System Development
Endoderm Development
Heart Development
Dorsal/ventral Axis Specification
Anterior/posterior Pattern Specification
Dorsal/ventral Pattern Formation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Cardiac Muscle Cell Apoptotic Process
Neural Crest Cell Development
Negative Regulation Of Smooth Muscle Cell Migration
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Neural Plate Mediolateral Regionalization
Cell Differentiation
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta2 Production
Somatic Stem Cell Population Maintenance
Hindlimb Morphogenesis
Dorsal Aorta Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Paraxial Mesoderm Structural Organization
Lateral Mesoderm Development
Regulation Of Lateral Mesodermal Cell Fate Specification
Mesendoderm Development
Embryonic Organ Development
Developmental Growth
Embryonic Morphogenesis
Stem Cell Differentiation
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Neurogenesis
Negative Regulation Of Muscle Cell Differentiation
Cartilage Development
Roof Of Mouth Development
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Neural Plate Pattern Specification
Heart Formation
Atrioventricular Node Cell Development
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Dendrite Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Cardiac Ventricle Development
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Fibrous Ring Of Heart Morphogenesis
Regulation Of Neural Crest Cell Differentiation
Anti-Mullerian Hormone Receptor Signaling Pathway
Regulation Of Cellular Senescence
Pathways
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by RAS GAP mutants
Signaling by RAS GTPase mutants
Signaling by BMP
Drugs
Hexane-1,6-Diol
Trifluoroethanol
Guanosine-5'-Triphosphate
Guanosine-5'-Diphosphate
N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Ursolic acid
Dibotermin alfa
Diseases
Penile cancer
Cervical cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Hepatocellular carcinoma
Thyroid cancer
Squamous cell carcinoma
Bladder cancer
Juvenile polyposis syndrome
Hereditary mixed polyposis syndrome
GWAS
Apolipoprotein A1 levels (
32203549
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
White blood cell count (
32888494
)
Interacting Genes
148 interacting genes:
ABR
ACTG1
AFDN
AGTR1
ANAPC1
ANKRD11
ANKRD16
ANKRD23
ANKRD34B
APBB1IP
ARAF
ARFGAP1
ARHGAP10
ARHGAP29
ARHGEF1
ARHGEF18
BCL2
BLID
BMPR1A
BRAF
BRAP
BUB1
CAV1
CDC123
CDC25A
CDC25C
CDH1
CDKN2A
CTNNA1
CXCL1
DEAF1
DGKE
DGKZ
DPP9
EIF3L
ERBB2
FBXW7
FNTA
FNTB
FYN
GPSM2
GPSM3
GRB2
GREB1
GRIN1
GRIN2D
HECTD1
HSPA12A
HSPA1L
ICMT
IKZF3
IL1RL1
IL24
IL3
INSR
IRAK1
IRAK2
ITGB3
ITSN1
KRAS
KRT17
KRT18
LGALS1
LZTR1
MAP2K1
MAP2K6
MAP3K6
MAPK10
MAPK8
MLH3
MSH2
MSH6
MTOR
MUTYH
NEDD4
NF1
NRAS
PDE4D
PDE6D
PDGFB
PDGFRL
PI4K2A
PIK3CA
PIK3CD
PIK3CG
PIK3R1
PLA2G4B
PLAAT4
PLCE1
PLCH2
PRKCI
PRKCZ
PRSS50
PTPRJ
QPCT
RAB5C
RABAC1
RABGEF1
RAF1
RALGDS
RAP1B
RAP1GDS1
RAPGEF1
RASA1
RASA2
RASA4
RASGRF1
RASGRP1
RASGRP4
RASIP1
RASSF1
RASSF2
RASSF5
RGL1
RGL2
RGL4
RGS12
RHOD
RIN1
RIT2
RNF115
RSPO3
SHOC2
SMAD4
SNRPE
SNX14
SNX17
SOS1
SOS2
SRC
STK11
STK38
TIAM1
TLR2
TLR6
TLR9
TP73
TTC1
TTC21A
TTC28
UBE3B
UBE4B
USP29
USP42
VAV1
ZBTB10
ZBTB12
ZDHHC9
45 interacting genes:
ACVR1
ALDOB
AOPEP
BAMBI
BMP2
BMP4
BMP5
BMP6
BMP7
BMPR1B
BMPR2
CDK8
CRIPTO
CTSV
FANCC
FBP1
FBP2
FKBP1A
FKBP1B
GALNT12
GDF5
GDF6
GDF9
HOXC8
HRAS
IGFBP3
MAP2K1
MSANTD3
NEDD4
NEDD4L
OTUB1
RASA1
SEC61B
SF3B4
SFRP2
SFRP4
SMAD1
TAB1
TGFB1
TGFBRAP1
TRMO
USP15
XPA
ZMYND11
ZNF189
Entrez ID
3265
657
HPRD ID
01813
03192
Ensembl ID
ENSG00000174775
ENSG00000107779
Uniprot IDs
P01112
X5D945
P36894
PDB IDs
121P
1AA9
1AGP
1BKD
1CLU
1CRP
1CRQ
1CRR
1CTQ
1GNP
1GNQ
1GNR
1HE8
1IAQ
1IOZ
1JAH
1JAI
1K8R
1LF0
1LF5
1LFD
1NVU
1NVV
1NVW
1NVX
1P2S
1P2T
1P2U
1P2V
1PLJ
1PLK
1PLL
1Q21
1QRA
1RVD
1WQ1
1XCM
1XD2
1XJ0
1ZVQ
1ZW6
221P
2C5L
2CE2
2CL0
2CL6
2CL7
2CLC
2CLD
2EVW
2LCF
2LWI
2N42
2N46
2Q21
2QUZ
2RGA
2RGB
2RGC
2RGD
2RGE
2RGG
2UZI
2VH5
2X1V
3DDC
3I3S
3K8Y
3K9L
3K9N
3KKM
3KKN
3KUD
3L8Y
3L8Z
3LBH
3LBI
3LBN
3LO5
3OIU
3OIV
3OIW
3RRY
3RRZ
3RS0
3RS2
3RS3
3RS4
3RS5
3RS7
3RSL
3RSO
3TGP
421P
4DLR
4DLS
4DLT
4DLU
4DLV
4DLW
4DLX
4DLY
4DLZ
4DST
4DSU
4EFL
4EFM
4EFN
4G0N
4G3X
4K81
4L9S
4L9W
4NYI
4NYJ
4NYM
4Q21
4RSG
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
4XVQ
4XVR
521P
5B2Z
5B30
5E95
5P21
5VBE
5VBZ
5WDO
5WDP
5WDQ
5WFO
5WFP
5WFQ
5WFR
5WPL
5X9S
5ZC6
621P
6AMB
6AXG
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6DZH
6E6C
6E6P
6MQT
6NTC
6NTD
6Q21
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6ZJ0
6ZL3
721P
7DPH
7DPJ
7JHP
7JIF
7JIG
7JIH
7JII
7L0F
7L0G
7OG9
7OGA
7OGB
7OGC
7OGD
7OGE
7OGF
7TAM
7VV8
7VV9
7VVG
821P
8BE6
8BE7
8BE8
8BE9
8BEA
8BOS
8BWG
8CNJ
8CNN
8ELK
8ELR
8ELS
8ELT
8ELU
8ELV
8ELW
8ELX
8ELY
8ELZ
8EM0
8FG3
8FG4
8OSM
8OSN
8OSO
8TBG
8TLR
8WWC
1ES7
1REW
2GOO
2H62
2H64
2K3G
2QJ9
2QJA
2QJB
3NH7
3QB4
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Intracellular Signaling Cassette
Ras Protein Signal Transduction
Regulation Of Intracellular Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Cytosol
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Guanyl-nucleotide Exchange Factor Activity
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Activation
Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
MAPK Cascade
Positive Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-activating Signaling Pathway
Cytoplasm
Positive Regulation Of MAPK Cascade
Regulation Of Cell Activation
Leukocyte Activation
Regulation Of Cellular Component Organization
Kinase Activity
Regulation Of Protein Serine/threonine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Adhesion
Protein Kinase Activity
Regulation Of Programmed Cell Death
Activation Of Immune Response
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Immune Response
Regulation Of Ras Protein Signal Transduction
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Defense Response
Plasma Membrane
Lymphocyte Activation
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Regulation Of Cartilage Development
Positive Regulation Of Signal Transduction
Cellular Response To BMP Stimulus
Regulation Of Osteoblast Differentiation
Transforming Growth Factor Beta Receptor Signaling Pathway
Growth Factor Activity
Cartilage Development
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Bone Mineralization
Positive Regulation Of Intracellular Signal Transduction
Osteoblast Differentiation
Positive Regulation Of Biomineral Tissue Development
BMP Receptor Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Ossification
Anatomical Structure Morphogenesis
Regulation Of Signal Transduction
Positive Regulation Of Cell Differentiation
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Ossification
Regulation Of Bone Mineralization
Positive Regulation Of Developmental Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Population Proliferation
Cytokine Activity
Regulation Of Primary Metabolic Process
Pattern Specification Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Animal Organ Morphogenesis
Response To Growth Factor
Mesenchyme Development
Positive Regulation Of Epithelial To Mesenchymal Transition
Endocardial Cushion Formation
Signal Transduction
Regulation Of RNA Metabolic Process
Heart Development
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Tagcloud (Intersection)
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