FBXO45 and TP73

Number of citations of the paper that reports this interaction (PMID 19581926)
20

Data Source:
BioGRID (enzymatic study)

		FBXO45	TP73
Gene Name		F-box protein 45	tumor protein p73
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Cell Junction Presynaptic Membrane Postsynaptic Membrane	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Neuron Migration Cellular Response To DNA Damage Stimulus Protein Ubiquitination Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Corticospinal Tract Morphogenesis Anterior Commissure Morphogenesis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Synapse Assembly Involved In Innervation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To X-ray Response To Organonitrogen Compound Response To Gamma Radiation Regulation Of Gene Expression Hippocampus Development Mitotic G1 DNA Damage Checkpoint Cerebrospinal Fluid Secretion Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Drugs
Diseases
GWAS			Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		2 interactors: PAWR TP73	50 interactors: ABL1 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP DAXX EP300 FBXO45 GNB2L1 HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PML PPP1R13B RANBP9 RBX1 RCHY1 SMAD2 SMAD3 SUMO1 TDG TP53 TP63 UBE2I WT1 WWOX XPO1 YAP1
Entrez ID		200933	7161
HPRD ID		19508	03587
Ensembl ID		ENSG00000174013	ENSG00000078900
Uniprot IDs		P0C2W1	C9J521 O15350
PDB IDs			1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Interleukin-2 Biosynthetic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cerebrospinal Fluid Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Interleukin-2 Production Positive Regulation Of Cell Death Negative Regulation Of Cell Proliferation Negative Regulation Of JUN Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Cell Size Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Apoptotic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cardiac Muscle Tissue Development Programmed Cell Death Cytokine Biosynthetic Process Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytokine Metabolic Process Negative Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Negative Regulation Of JNK Cascade Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of B Cell Activation Negative Regulation Of Gene Expression Negative Regulation Of Organ Growth Positive Regulation Of Glial Cell Differentiation Negative Regulation Of Biosynthetic Process	Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Apoptotic Process Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Regulation Of Signal Transduction Cell Death Cellular Response To Stress Death Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		asd asds autism connectivity contributors deleterious hamartin idiopathic intronic mounting mtorc1 mycbp2 neurodevelopment pam pools proband representation resequenced rheb sanger simons splice synapse trios tsc tsc1 tsc2 tuberin variants	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Difference) ?		asd asds autism connectivity contributors deleterious hamartin idiopathic intronic mounting mtorc1 mycbp2 neurodevelopment pam pools proband representation resequenced rheb sanger simons splice synapse trios tsc tsc1 tsc2 tuberin variants	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Intersection) ?