DFFB and CIDEB

Number of citations of the paper that reports this interaction (PMID 10619428)
22

Data Source:
HPRD (in vivo, in vitro)

		DFFB	CIDEB
Gene Name		DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	cell death-inducing DFFA-like effector b
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol	Lipid Particle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Deoxyribonuclease Activity Enzyme Binding	Protein Binding Identical Protein Binding
	Biological Process	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Apoptotic Chromosome Condensation	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity
Pathways		Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		4 interactors: APP CIDEB DFFA TOP2A	3 interactors: CIDEA DFFA DFFB
Entrez ID		1677	27141
HPRD ID		03532	11981
Ensembl ID		ENSG00000169598	ENSG00000136305
Uniprot IDs		O76075	Q9UHD4
PDB IDs		1IBX	1D4B
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Nuclear Changes Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Chromosome Condensation Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Cell Death Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Apoptotic DNA Fragmentation Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Neuron Remodeling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Embryonic Cleavage DNA Unwinding Involved In DNA Replication Resolution Of Meiotic Recombination Intermediates DNA Ligation T Cell Apoptotic Process Cellular Copper Ion Homeostasis Apoptotic DNA Fragmentation Positive Regulation Of Viral Genome Replication Chromosome Separation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Mitotic Recombination Neuron Maturation MRNA Polyadenylation	Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Execution Phase Of Apoptosis Apoptotic DNA Fragmentation Regulation Of Execution Phase Of Apoptosis Apoptotic Nuclear Changes Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis DNA Catabolic Process, Endonucleolytic Apoptotic Process Programmed Cell Death Cell Death Death DNA Catabolic Process Negative Regulation Of Apoptotic DNA Fragmentation Nucleic Acid Phosphodiester Bond Hydrolysis Apoptotic Chromosome Condensation Positive Regulation Of Sequestering Of Triglyceride Thymocyte Apoptotic Process Aromatic Compound Catabolic Process Response To Stilbenoid T Cell Apoptotic Process Negative Regulation Of Lipid Catabolic Process Temperature Homeostasis Cellular Macromolecule Catabolic Process Positive Regulation Of Lipid Storage Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cytokine Secretion Negative Regulation Of Cell Death Negative Regulation Of Tumor Necrosis Factor Production Lipid Storage Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production DNA Metabolic Process Chromosome Condensation Regulation Of Lipid Catabolic Process Regulation Of Lipid Storage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Apoptotic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Death Negative Regulation Of DNA Metabolic Process Negative Regulation Of Protein Secretion Nitrogen Compound Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2	87mg ags alteration arrayed bad bcl2 bcl2l11 bfar bnip3l casp7 cidea combat endows exceptions irrelevant oct4 oct4b1 pluripotent sirnas spliced stream tenfold tnfrsf10b tnfrsf11b tnfrsf1a tnfrsf21 tp73 traf3 uncovering
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top trp53bp2	87mg ags alteration arrayed bad bcl2 bcl2l11 bfar bnip3l casp7 cidea combat endows exceptions irrelevant oct4 oct4b1 pluripotent sirnas spliced stream tenfold tnfrsf10b tnfrsf11b tnfrsf1a tnfrsf21 tp73 uncovering
Tagcloud (Intersection) ?		traf3