DFFB

Gene Name		DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Deoxyribonuclease Activity Enzyme Binding
	Biological Process	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Apoptotic Chromosome Condensation
Pathways		Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)
Protein-protein Interactions		4 interactors: APP CIDEB DFFA TOP2A
Entrez ID		1677
HPRD ID		03532
Ensembl ID		ENSG00000169598
Uniprot IDs		O76075
PDB IDs		1IBX
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Nuclear Changes Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Chromosome Condensation Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Cell Death Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Apoptotic DNA Fragmentation Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Neuron Remodeling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Embryonic Cleavage DNA Unwinding Involved In DNA Replication Resolution Of Meiotic Recombination Intermediates DNA Ligation T Cell Apoptotic Process Cellular Copper Ion Homeostasis Apoptotic DNA Fragmentation Positive Regulation Of Viral Genome Replication Chromosome Separation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Mitotic Recombination Neuron Maturation MRNA Polyadenylation
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2