DFFB

Description		DNA fragmentation factor subunit beta
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA Binding Nuclease Activity DNA Endonuclease Activity DNA Nuclease Activity Protein Binding Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Apoptotic Chromosome Condensation Negative Regulation Of Apoptotic DNA Fragmentation
Pathways		Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: APP CIDEB DFFA TOP2A
Entrez ID		1677
HPRD ID		03532
Ensembl ID		ENSG00000169598
Uniprot IDs		B4DZS0 O76075 Q96P72 Q96P73 Q96P74
PDB IDs		1IBX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Apoptotic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Lipoprotein Particle Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apoptotic DNA Fragmentation Deoxyribonuclease Inhibitor Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Nuclease Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Apoptotic Chromosome Condensation Lipid Droplet Fusion Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition DNA Topoisomerase Activity
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