DFFB and DFFA

Number of citations of the paper that reports this interaction (PMID 9422506)
292

Data Source:
HPRD (in vitro, in vivo)

		DFFB	DFFA
Gene Name		DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	DNA fragmentation factor, 45kDa, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Lipid Particle Cytosol
	Molecular Function	Deoxyribonuclease Activity Enzyme Binding	Protein Binding
	Biological Process	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Apoptotic Chromosome Condensation	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation
Pathways		Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase	Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		4 interactors: APP CIDEB DFFA TOP2A	11 interactors: CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ
Entrez ID		1677	1676
HPRD ID		03532	03531
Ensembl ID		ENSG00000169598
Uniprot IDs		O76075	O00273
PDB IDs		1IBX	1IBX 1IYR 1KOY
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Nuclear Changes Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Chromosome Condensation Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Cell Death Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Apoptotic DNA Fragmentation Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Neuron Remodeling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Embryonic Cleavage DNA Unwinding Involved In DNA Replication Resolution Of Meiotic Recombination Intermediates DNA Ligation T Cell Apoptotic Process Cellular Copper Ion Homeostasis Apoptotic DNA Fragmentation Positive Regulation Of Viral Genome Replication Chromosome Separation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Mitotic Recombination Neuron Maturation MRNA Polyadenylation	Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Protein Processing Activation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Zymogen Activation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Positive Regulation Of Organelle Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic DNA Fragmentation Positive Regulation Of Peptidase Activity Intracellular Signal Transduction Cytolysis Apoptotic Nuclear Changes Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Proteolysis Regulation Of Organelle Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cellular Component Organization DNA Catabolic Process, Endonucleolytic Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Catabolic Process Golgi Reassembly Apoptotic Chromosome Condensation Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2	cd40 cd71 dysplastic effector erythroid erythropoiesis etv6 fas glya gm hematopoiesis hemoglobin ineffective leukemic making megakaryocyte meps microrna mir9 mirna mirnas profiling progenitors robust runx1 sorted speculating sub ut
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2	cd40 cd71 dysplastic effector erythroid erythropoiesis etv6 fas glya gm hematopoiesis hemoglobin ineffective leukemic making megakaryocyte meps microrna mir9 mirna mirnas profiling progenitors robust runx1 sorted speculating sub ut
Tagcloud (Intersection) ?