DFFB and DFFA

Number of citations of the paper that reports this interaction (PubMedID 11371636)
26

Data Source:
HPRD (in vitro, in vivo)

		DFFB	DFFA
Description		DNA fragmentation factor subunit beta	DNA fragmentation factor subunit alpha
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	DNA Binding Nuclease Activity DNA Endonuclease Activity DNA Nuclease Activity Protein Binding Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Disordered Domain Specific Binding	Protein Binding Protein Domain Specific Binding Protein Folding Chaperone Deoxyribonuclease Inhibitor Activity
	Biological Process	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Apoptotic Chromosome Condensation Negative Regulation Of Apoptotic DNA Fragmentation	Apoptotic DNA Fragmentation Protein Folding Apoptotic Process Negative Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation
Pathways		Apoptosis induced DNA fragmentation	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494) Metabolite levels ( 23823483)	Depression in smokers ( 30219690) Male-pattern baldness ( 28196072 29146897)
Interacting Genes		4 interacting genes: APP CIDEB DFFA TOP2A	12 interacting genes: AGO2 CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ
Entrez ID		1677	1676
HPRD ID		03532	03531
Ensembl ID		ENSG00000169598	ENSG00000160049
Uniprot IDs		B4DZS0 O76075 Q96P72 Q96P73 Q96P74	O00273
PDB IDs		1IBX	1IBX 1IYR 1KOY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Apoptotic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Lipoprotein Particle Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apoptotic DNA Fragmentation Deoxyribonuclease Inhibitor Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Nuclease Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Apoptotic Chromosome Condensation Lipid Droplet Fusion Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition DNA Topoisomerase Activity	Execution Phase Of Apoptosis Cellular Response To Staurosporine Pyroptotic Inflammatory Response Cell Death Apoptotic Process Programmed Cell Death Protein Domain Specific Binding Fibroblast Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Positive Regulation Of Immune Response To Tumor Cell Regulation Of Amyloid Precursor Protein Biosynthetic Process Aspartic-type Endopeptidase Activity Regulation Of Primary Metabolic Process Regulation Of Synapse Maturation Peptidase Activity Plasma Membrane Repair Regulation Of Response To Tumor Cell Negative Regulation Of Translation Cellular Response To Alkaloid Regulation Of Glycoprotein Biosynthetic Process Hydrolase Activity Cytoplasm Protein Sequestering Activity Leukocyte Apoptotic Process Neuron Recognition Glutamatergic Synapse Negative Regulation Of Translational Initiation Postsynapse Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Ceramide Biosynthetic Process Identical Protein Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Regulation Of Metabolic Process Proteolysis Cysteine-type Endopeptidase Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Synapse Organization Striated Muscle Cell Differentiation Response To External Biotic Stimulus Phospholipase A2 Activator Activity Cytolytic Granule Lumen Leukocyte Mediated Cytotoxicity Synaptic Target Recognition Endoribonuclease Activity, Cleaving MiRNA-paired MRNA Negative Regulation Of G Protein-coupled Receptor Internalization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?