TNNI1 and TNNC1

Number of citations of the paper that reports this interaction (PMID 15542288)
40

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vivo)

		TNNI1	TNNC1
Gene Name		troponin I type 1 (skeletal, slow)	troponin C type 1 (slow)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Nucleoplasm Mitochondrion Cytosol Troponin Complex Actin Cytoskeleton
	Molecular Function	Actin Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Striated Muscle Contraction Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis	Diaphragm Contraction Regulation Of Muscle Contraction Response To Metal Ion Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs			Trifluoperazine Levosimendan Felodipine Bepridil Calcium Dihydroxyaluminium 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		11 interactors: ACTA1 CCDC85B EIF3I MDFI PKD2L1 PNMA1 TNNC1 TNNT1 TNNT2 TRIM55 TRIM63	11 interactors: CDK1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBE2C
Entrez ID		7135	7134
HPRD ID		01842	08930
Ensembl ID		ENSG00000159173	ENSG00000114854
Uniprot IDs		P19237	P63316 Q6FH91
PDB IDs			1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Regulation Of Muscle Contraction Skeletal Muscle Contraction Actin Filament-based Process Regulation Of ATPase Activity Musculoskeletal Movement Ventricular Cardiac Muscle Tissue Morphogenesis Muscle Organ Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Tissue Development Muscle Tissue Morphogenesis Response To Metal Ion Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Muscle Filament Sliding Speed Myofibril Assembly Striated Muscle Contraction Skeletal Muscle Fiber Adaptation Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiac Ventricle Development Response To Inorganic Substance Actomyosin Structure Organization Muscle Structure Development Regulation Of Muscle Filament Sliding Diaphragm Contraction Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Cardiac Chamber Development Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction Striated Muscle Cell Development Skeletal Muscle Atrophy Muscle Cell Development Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Cardiac Muscle Tissue Development Movement Of Cell Or Subcellular Component Cellular Response To Acidic PH Muscle Atrophy Atrial Cardiac Muscle Tissue Morphogenesis	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of ATPase Activity Actin Filament-based Process Striated Muscle Contraction Striated Muscle Tissue Development Muscle Tissue Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Cardiac Chamber Development Muscle Structure Development Heart Development Skeletal Muscle Contraction Heart Morphogenesis Regulation Of ATPase Activity Musculoskeletal Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Muscle Organ Development Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Cardiovascular System Development Pronuclear Fusion Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of MRNA Processing Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination
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