TNNI1 and PKD2L1

Number of citations of the paper that reports this interaction (PMID 12809519)
4

Data Source:
BioGRID (pull down)

		TNNI1	PKD2L1
Gene Name		troponin I type 1 (skeletal, slow)	polycystic kidney disease 2-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Nonmotile Primary Cilium Calcium Channel Complex Intracellular Membrane-bounded Organelle Receptor Complex Ciliary Membrane
	Molecular Function	Actin Binding Metal Ion Binding	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Regulation Of Striated Muscle Contraction Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Cation Transport Smoothened Signaling Pathway Sodium Ion Transmembrane Transport Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 22359512)
Protein-Protein Interactions		11 interactors: ACTA1 CCDC85B EIF3I MDFI PKD2L1 PNMA1 TNNC1 TNNT1 TNNT2 TRIM55 TRIM63	3 interactors: TNNI1 TNNI2 TNNI3
Entrez ID		7135	9033
HPRD ID		01842	16063
Ensembl ID		ENSG00000159173	ENSG00000107593
Uniprot IDs		P19237	Q1L4F0 Q9P0L9
PDB IDs			3TE3 4GIF
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Regulation Of Muscle Contraction Skeletal Muscle Contraction Actin Filament-based Process Regulation Of ATPase Activity Musculoskeletal Movement Ventricular Cardiac Muscle Tissue Morphogenesis Muscle Organ Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Tissue Development Muscle Tissue Morphogenesis Response To Metal Ion Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Muscle Filament Sliding Speed Myofibril Assembly Striated Muscle Contraction Skeletal Muscle Fiber Adaptation Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiac Ventricle Development Response To Inorganic Substance Actomyosin Structure Organization Muscle Structure Development Regulation Of Muscle Filament Sliding Diaphragm Contraction Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Cardiac Chamber Development Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction Striated Muscle Cell Development Skeletal Muscle Atrophy Muscle Cell Development Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Cardiac Muscle Tissue Development Movement Of Cell Or Subcellular Component Cellular Response To Acidic PH Muscle Atrophy Atrial Cardiac Muscle Tissue Morphogenesis	Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Regulation Of Muscle Contraction Muscle Contraction Muscle System Process Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Actin Filament-based Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Striated Muscle Contraction Cardiac Ventricle Development Cardiac Chamber Development Cardiac Muscle Tissue Development Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Movement Of Cell Or Subcellular Component Heart Morphogenesis Muscle Organ Development Striated Muscle Tissue Development Muscle Tissue Development Negative Regulation Of ATPase Activity Muscle Structure Development Heart Development Tissue Morphogenesis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Skeletal Muscle Contraction Cardiovascular System Development Regulation Of ATPase Activity Organ Morphogenesis Musculoskeletal Movement Cardiac Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Contraction Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Vasculogenesis Tissue Development Regulation Of Blood Pressure
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