TNNI1 and PKD2L1

Number of citations of the paper that reports this interaction (PubMedID 12809519)
0

Data Source:
BioGRID (pull down)

		TNNI1	PKD2L1
Description		troponin I1, slow skeletal type	polycystin 2 like 1, transient receptor potential cation channel
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Cell Surface Actin Cytoskeleton Membrane Cytoplasmic Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Receptor Complex Ciliary Membrane Non-motile Cilium
	Molecular Function	Actin Binding Protein Binding	Calcium-activated Cation Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Monoatomic Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Actinin Binding Transmembrane Transporter Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity Muscle Alpha-actinin Binding Alpha-actinin Binding PH-gated Monoatomic Ion Channel Activity Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	Skeletal Muscle Contraction Regulation Of Striated Muscle Contraction Transition Between Fast And Slow Fiber Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Smoothened Signaling Pathway Response To Water Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Tetramerization Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To PH Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 30224653) Fatty acid desaturase activity (adipose tissue) ( 30453627) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean platelet volume ( 27863252 32888494) Obesity-related traits ( 23251661) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 24625756 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Squamous cell lung carcinoma ( 28604730) Vaccenic acid (18:1n-7) levels ( 28298293)
Interacting Genes		46 interacting genes: ACTA1 ANKRD11 ARMC7 C2orf68 CABP2 CABP5 CCDC102B CCDC57 CCDC85B CDCA7L CEP19 CETN3 CTNNA3 DCAF11 DRC8 EAF1 EIF1AD EIF3B ENKD1 ESRRG KIFC3 L3MBTL2 MBD3 MCRS1 MDFI MNS1 MTUS2 PIH1D2 PIK3R3 PKD2L1 PNMA1 POLR1C PRKAB2 SAT1 SCNM1 SPANXN2 SYCE1L TNNC1 TNNT1 TNNT2 TPM3 TRIM41 TRIM55 TRIM63 USP20 ZNF76	4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3
Entrez ID		7135	9033
HPRD ID		01842	16063
Ensembl ID		ENSG00000159173	ENSG00000107593
Uniprot IDs		P19237	Q1L4F0 Q9P0L9
PDB IDs			3TE3 4GIF 6DU8
Enriched GO Terms of Interacting Partners?		Cytoskeleton Troponin Complex Centrosome Muscle Contraction Cardiac Troponin Complex Troponin I Binding Troponin T Binding Muscle System Process Centriole Transition Between Fast And Slow Fiber Striated Muscle Thin Filament Microtubule Regulation Of Skeletal Muscle Adaptation Sarcomere Contractile Muscle Fiber Tropomyosin Binding Regulation Of Muscle System Process Cytoplasm Muscle Filament Sliding Protein Binding Actin-myosin Filament Sliding Spindle Pole	Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Troponin T Binding Striated Muscle Contraction Muscle Contraction Muscle System Process Actin Binding Ventricular Cardiac Muscle Tissue Morphogenesis System Process Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Mesaxon Regulation Of Muscle Contraction Cardiac Troponin Complex Troponin C Binding Regulation Of Transepithelial Transport Regulation Of Muscle System Process Transition Between Fast And Slow Fiber Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Myofibril Apical Junction Assembly Paracellular Tight Junction Channel Activity Retinal Pigment Epithelium Development Paracellular Transport Paranodal Junction Regulation Of Skeletal Muscle Adaptation Schmidt-Lanterman Incisure Action Potential Propagation Neuronal Action Potential Propagation Negative Regulation Of ATP-dependent Activity Tissue Morphogenesis Actin Filament-based Process Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Actin-myosin Filament Sliding Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Heart Contraction Regulation Of System Process Apical Junction Complex Heart Process Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell-cell Adhesion Mediator Activity Tight Junction Actin-mediated Cell Contraction Renal Absorption
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