CYB5R3 and VAMP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB5R3	VAMP5
Description		cytochrome b5 reductase 3	vesicle associated membrane protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Endomembrane System Intercalated Disc Membrane Cytoplasmic Vesicle Membrane Organelle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process	Muscle Organ Development Skeletal Muscle Tissue Development Vesicle-mediated Transport Cell Differentiation Golgi To Plasma Membrane Protein Transport
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia
GWAS		Initial pursuit acceleration ( 29064472)	Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Platelet distribution width ( 32888494) Prostate cancer ( 21743467) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15	57 interacting genes: ABHD16A AQP6 ARL13B ASGR2 ATP6AP2 BIK CD53 CLDN5 CLDN7 COMT CPLX4 CYB5R3 ELOVL4 ERGIC3 FAM209A FNDC9 GJA8 GORAB GPR152 GPX8 GRAMD2B HIBADH HSD17B13 IL3RA JAGN1 KIR2DL3 KIR3DL3 KLRC1 LMNA LRRC25 MDC1 MUC1 NCAPH2 PANX1 PLAC8 PVR RETREG3 SAR1A SLC14A2 SLC18A1 SPINT1 STX1A STX1B STX2 TAS2R5 TM4SF18 TMCO5A TMEM106C TMEM139 TMEM14B TMEM31 TMEM45B TMEM52B TMEM86B TMPRSS2 TMX2 VSIG4
Entrez ID		1727	10791
HPRD ID		08942	09513
Ensembl ID		ENSG00000100243	ENSG00000168899
Uniprot IDs		P00387	O95183 Q6FG93
PDB IDs		1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport	Membrane Protein Binding SNARE Complex Endoplasmic Reticulum Membrane SNARE Binding Endoplasmic Reticulum Presynaptic Active Zone Membrane Synaptic Vesicle Exocytosis Monoatomic Anion Channel Activity Signal Release Norepinephrine Transport Structural Molecule Activity SNAP Receptor Activity Neurotransmitter Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Exocytosis Regulation Of Synaptic Vesicle Priming
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