CYB5R3 and YIPF4

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		CYB5R3	YIPF4
Description		cytochrome b5 reductase 3	Yip1 domain family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia
GWAS		Initial pursuit acceleration ( 29064472)	Chronotype ( 30696823) Male-pattern baldness ( 28196072) Refractive error ( 32231278)
Interacting Genes		78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15	37 interacting genes: AQP6 ARL6IP1 BIK CD79A CNR2 CYB5R3 EBP ERGIC3 FAM209A FATE1 FCER1G FKBP7 GPR152 GPR42 HSD17B13 IER3IP1 NAT8 REEP4 RNF185 RNF5 SCN3B SLC10A1 SLC18A1 SLC30A8 SLC35A4 SLC35H1 SLC71A2 SLC7A1 SLC7A14 TIMMDC1 TLCD4 TMEM14B TSNARE1 TVP23B YIF1A YIPF3 ZDHHC15
Entrez ID		1727	84272
HPRD ID		08942	14410
Ensembl ID		ENSG00000100243	ENSG00000119820
Uniprot IDs		P00387	Q9BSR8
PDB IDs		1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport	Membrane Endoplasmic Reticulum Transmembrane Transport Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transporter Activity Zinc:proton Antiporter Activity Mitochondrial Membrane COPII-coated ER To Golgi Transport Vesicle Ubiquitin-like Protein Conjugating Enzyme Binding Pyrimidine Nucleotide-sugar Transmembrane Transport Zinc Ion Import Into Organelle Nucleotide-sugar Transmembrane Transport Serotonin Transport Endoplasmic Reticulum Organization Endoplasmic Reticulum Mannose Trimming Golgi Membrane Protein Alpha-1,2-demannosylation Monoatomic Cation Transmembrane Transporter Activity Insulin Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Deglycosylation Endoplasmic Reticulum Tubular Network Organization Protein Binding Endoplasmic Reticulum Tubular Network Zinc Ion Transmembrane Transporter Activity Endoplasmic Reticulum Quality Control Compartment Antiporter Activity Zinc Ion Transmembrane Transport
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