CYB5R3 and VAMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB5R3	VAMP1
Description		cytochrome b5 reductase 3	vesicle associated membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Azurophil Granule Membrane Specific Granule Membrane Neuron Projection Synapse Tertiary Granule Membrane
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process	Vesicle Fusion Vesicle-mediated Transport SNARE Complex Assembly
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation	Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type G (botG)
Drugs		NADH Flavin adenine dinucleotide Copper	Botulinum toxin type B
Diseases		Methemoglobinemia
GWAS		Initial pursuit acceleration ( 29064472)	Hip geometry ( 17903296)
Interacting Genes		78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15	37 interacting genes: AQP6 ARL13B BCAP31 CDKN2A CRB3 CREB3L1 CYB5R3 DNAJC5 EBP ELOVL4 ELOVL7 ERGIC3 FAM210B FCER1G GPR152 KASH5 LAPTM5 LMNA REEP4 RETREG3 RNF24 SCN3B SEC11C SGMS2 SLC10A6 SLC30A8 SNAP23 SNAP29 STX1A STX1B STX4 TMEM101 TMEM14B TMEM35A TMX2 VAPA VAPB
Entrez ID		1727	6843
HPRD ID		08942	01716
Ensembl ID		ENSG00000100243	ENSG00000139190
Uniprot IDs		P00387	F5GZV7 P23763
PDB IDs		1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport	Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Organelle Localization By Membrane Tethering Membrane Docking SNARE Complex Membrane Organization Secretion By Cell Exocytosis Organelle Localization Membrane Fusion Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Signal Release Intracellular Protein Localization Endoplasmic Reticulum Vesicle Fusion To Plasma Membrane Vesicle Fusion Organelle Membrane Fusion Vesicle-mediated Transport Vesicle Organization Synaptic Vesicle Membrane Organization Positive Regulation Of Protein Localization To Cell Surface Organelle Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell FFAT Motif Binding Golgi Vesicle Transport Positive Regulation Of Protein Localization COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Synaptic Vesicle Exocytosis Sphingolipid Biosynthetic Process Cytoplasmic Vesicle Regulated Exocytosis Regulation Of Protein Localization To Cell Surface Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid ATP-dependent Protein Binding Endoplasmic Reticulum Localization Regulation Of Protein Localization Fatty Acid Elongation, Saturated Fatty Acid Protein Binding Presynapse Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Regulated Secretory Pathway Azurophil Granule Membrane Host-mediated Activation Of Viral Genome Replication
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