C1QC and ZNF534

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		C1QC	ZNF534
Name		complement C1q C chain	zinc finger protein 534
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface	Nucleus
	Molecular Function	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Immune System Process Immune Response Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	None
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: RALA	None recorded
Interacting Genes		6 interacting genes: C1QA C1QB FKBP2 PTX3 UBQLN2 ZNF534	3 interacting genes: AGAP1 C1QC WDR83OS
Entrez ID		714	147658
HPRD ID		00395	15824
Ensembl ID		ENSG00000159189	ENSG00000198633
Uniprot IDs		A0A024RAA7 A0A8Q3SIZ0 P02747	Q1T7F5 Q1T7F6 Q76KX8
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U	Not available
GO Terms Enriched among Interactors		Complement Component C1q Complex IgM Binding Complement Component C1 Complex Synapse Pruning IgG Binding Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Regulation Of Endocytosis Phosphatidylserine Binding Immune Effector Process Collagen Trimer Regulation Of Receptor Internalization Extracellular Matrix Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Receptor-mediated Endocytosis Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Surface Innate Immune Response Ovarian Cumulus Expansion Negative Regulation Of Clathrin-dependent Endocytosis Defense Response To Symbiont Defense Response To Other Organism Extrinsic Component Of Postsynaptic Membrane Complement Component C1q Complex Binding Membrane Raft Localization Postsynapse FK506 Binding Virion Binding Synapse Organization Humoral Immune Response Neuron Remodeling Response To Yeast Host-mediated Suppression Of Viral Proces Negative Regulation Of Receptor Internalization Astrocyte Activation Negative Regulation Of Glycoprotein Metabolic Process Opsonization Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Response To Other Organism	Complement Component C1q Complex Complement Component C1 Complex Negative Regulation Of Granulocyte Differentiation IgM Binding Extrinsic Component Of Postsynaptic Membrane Extrinsic Component Of Presynaptic Membrane Negative Regulation Of Macrophage Differentiation Synapse Pruning Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Postsynaptic Endosome Regulation Of Granulocyte Differentiation IgG Binding Regulation Of Modification Of Postsynaptic Structure Symbiont Cell Surface Regulation Of Modification Of Synaptic Structure Regulation Of Macrophage Differentiation Protein Insertion Into ER Membrane Protein Folding Chaperone Complex Complement Activation, Classical Pathway Complement Activation Negative Regulation Of Myeloid Leukocyte Differentiation Phosphatidylserine Binding Protein Folding Chaperone