C1QC and PTX3

Number of citations of the paper that reports this interaction (PubMedID 12645945)
0

Data Source:
HPRD (in vitro)

		C1QC	PTX3
Description		complement C1q C chain	pentraxin 3
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	Immune System Process Immune Response Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning	Ovarian Cumulus Expansion Response To Yeast Immune System Process Inflammatory Response Immune Response Opsonization Extracellular Matrix Organization Host-mediated Suppression Of Viral Proces Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Phagocytosis Response To Other Organism Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Neutrophil degranulation
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Blood protein levels ( 30072576)	Body mass index ( 26426971)
Interacting Genes		6 interacting genes: C1QA C1QB FKBP2 PTX3 UBQLN2 ZNF534	16 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A SNCA
Entrez ID		714	5806
HPRD ID		00395	03928
Ensembl ID		ENSG00000159189	ENSG00000163661
Uniprot IDs		A0A024RAA7 A0A8Q3SIZ0 P02747	P26022
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U	7ZL1 8PVQ 8S50
Enriched GO Terms of Interacting Partners?		Complement Component C1q Complex IgM Binding Complement Component C1 Complex Synapse Pruning IgG Binding Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Regulation Of Endocytosis Phosphatidylserine Binding Immune Effector Process Collagen Trimer Regulation Of Receptor Internalization Extracellular Matrix Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Receptor-mediated Endocytosis Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Surface Innate Immune Response Ovarian Cumulus Expansion Negative Regulation Of Clathrin-dependent Endocytosis Defense Response To Symbiont Defense Response To Other Organism Extrinsic Component Of Postsynaptic Membrane Complement Component C1q Complex Binding Membrane Raft Localization Postsynapse FK506 Binding Virion Binding Synapse Organization Humoral Immune Response Neuron Remodeling Response To Yeast Host-mediated Suppression Of Viral Proces Negative Regulation Of Receptor Internalization Astrocyte Activation Negative Regulation Of Glycoprotein Metabolic Process Opsonization Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Response To Other Organism	Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Growth Factor Activity Fibroblast Growth Factor Receptor Binding Extracellular Region Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Type 2 Fibroblast Growth Factor Receptor Binding Extracellular Space Cell-cell Signaling Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Signaling Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of MAPK Cascade Regulation Of Locomotion Complement Component C1q Complex Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Population Proliferation Symbiont Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility IgM Binding Complement Component C1 Complex Positive Regulation Of Intracellular Signal Transduction Type 1 Fibroblast Growth Factor Receptor Binding Positive Regulation Of Cell Division Lung Development Postsynapse Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synapse Pruning Complement Activation Regulation Of Sprouting Angiogenesis IgG Binding Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Animal Organ Morphogenesis Organ Induction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Animal Organ Formation Corticotropin Hormone Secreting Cell Differentiation Developmental Induction Chemoattractant Activity Positive Regulation Of Endothelial Cell Migration
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