CR1 and FUT4

Number of citations of the paper that reports this interaction (PMID 3305706)
18

Data Source:
HPRD (in vivo)

		CR1	FUT4
Gene Name		complement component (3b/4b) receptor 1 (Knops blood group)	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Golgi Apparatus Cell Surface Membrane Integral Component Of Membrane Golgi Cisterna Membrane Cell Periphery
	Molecular Function	Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity	Fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity	Carbohydrate Metabolic Process Protein Glycosylation Fucosylation L-fucose Catabolic Process
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 19734903) Alzheimer's disease (late onset) ( 21460841) Erythrocyte sedimentation rate ( 21700265) Inflammatory biomarkers ( 22291609)	Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498)
Protein-Protein Interactions		6 interactors: C1QA C3 C4A CD55 CR2 FUT4	3 interactors: CR1 ITGB2 SELP
Entrez ID		1378	2526
HPRD ID		00398	00083
Ensembl ID		ENSG00000203710	ENSG00000196371
Uniprot IDs		E9PDY4 P17927	P22083
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2Q7Z
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Complement Activation Positive Regulation Of Immune Response Regulation Of Humoral Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Immune Response Regulation Of Immune System Process Defense Response Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Phagocytosis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Phagocytosis Protein Metabolic Process Positive Regulation Of Endocytosis Response To Stress Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Negative Regulation Of Catalytic Activity CD4-positive, Alpha-beta T Cell Cytokine Production Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Protein Metabolic Process Complement Receptor Mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity L-fucose Catabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Maternal Process Involved In Parturition T Cell Cytokine Production Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Respiratory Burst Negative Regulation Of Proteolysis	Cellular Extravasation Positive Regulation Of Immune System Process Positive Regulation Of Serine-type Endopeptidase Activity Regulation Of Immune System Process Defense Response Selenium Compound Metabolic Process Negative Regulation Of Complement Activation, Alternative Pathway Leukocyte Migration Regulation Of Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Leukocyte Cell-cell Adhesion Complement Receptor Mediated Signaling Pathway Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Platelet Activation Inflammatory Response Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Regulation Of Integrin Activation Leukocyte Migration Involved In Inflammatory Response Single Organismal Cell-cell Adhesion Leukocyte Tethering Or Rolling Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Complement Activation Positive Regulation Of Immune Response Cell Activation Response To Wounding Heterotypic Cell-cell Adhesion Activated T Cell Proliferation Response To Stress Innate Immune Response Cell Migration Regulation Of Platelet Activation Regulation Of Immune Response Positive Regulation Of Blood Coagulation Regulation Of Complement Activation Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Nitric Oxide Biosynthetic Process Defense Response To Gram-negative Bacterium Negative Regulation Of Adaptive Immune Response Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Innate Immune Response Positive Regulation Of Coagulation Neutrophil Chemotaxis
Tagcloud ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable	a431 abolished akt asssociated carbohydrate catalyzes cdk correlates crosstalk difucosylated erk1 fucosyltransferase herein lewis ley ly294002 mapk mapks oligosaccharide p27 p38 pd98059 phosphoinositide pi3k prb promotes sb203580 upstream wortmannin
Tagcloud (Difference) ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable	a431 abolished akt asssociated carbohydrate catalyzes cdk correlates crosstalk difucosylated erk1 fucosyltransferase herein lewis ley ly294002 mapk mapks oligosaccharide p27 p38 pd98059 phosphoinositide pi3k prb promotes sb203580 upstream wortmannin
Tagcloud (Intersection) ?