CR1 and CD55

Number of citations of the paper that reports this interaction (PMID 11694537)
15

Data Source:
HPRD (in vitro)

		CR1	CD55
Gene Name		complement component (3b/4b) receptor 1 (Knops blood group)	CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity	Virus Receptor Activity Protein Binding Lipid Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity	Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Virus Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Cytokine Production Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Regulation of Complement cascade Complement cascade Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Innate Immune System
Drugs			Chloramphenicol
Diseases
GWAS		Alzheimer's disease ( 21460840 19734903) Alzheimer's disease (late onset) ( 21460841) Erythrocyte sedimentation rate ( 21700265) Inflammatory biomarkers ( 22291609)
Protein-Protein Interactions		6 interactors: C1QA C3 C4A CD55 CR2 FUT4	6 interactors: CD14 CD97 CR1 FYN GPLD1 LCK
Entrez ID		1378	1604
HPRD ID		00398	00500
Ensembl ID		ENSG00000203710	ENSG00000196352
Uniprot IDs		E9PDY4 P17927	B1AP13 P08174
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2Q7Z	1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Complement Activation Positive Regulation Of Immune Response Regulation Of Humoral Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Immune Response Regulation Of Immune System Process Defense Response Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Phagocytosis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Phagocytosis Protein Metabolic Process Positive Regulation Of Endocytosis Response To Stress Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Negative Regulation Of Catalytic Activity CD4-positive, Alpha-beta T Cell Cytokine Production Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Protein Metabolic Process Complement Receptor Mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity L-fucose Catabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Maternal Process Involved In Parturition T Cell Cytokine Production Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Respiratory Burst Negative Regulation Of Proteolysis	Immune Response-regulating Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Complement Receptor Mediated Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cell Surface Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Innate Immune Response Positive Regulation Of Proteolysis Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Metal Ion Response To Abiotic Stimulus Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Inorganic Substance T Cell Costimulation Response To Peptide Regulation Of Defense Response To Virus Response To Drug Signaling Movement Of Cell Or Subcellular Component Cell Communication GPI Anchor Release Cellular Response To Triglyceride Positive Regulation Of Serine-type Endopeptidase Activity Cellular Response To Hormone Stimulus T Cell Receptor Signaling Pathway Response To Stress Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Ethanol Positive Regulation Of Endopeptidase Activity Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Complement Activation, Alternative Pathway Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Positive Regulation Of Peptidase Activity
Tagcloud ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable	abc accelerating acinar apical cd46 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Difference) ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable	abc accelerating acinar apical cd46 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Intersection) ?