CR1 and C4A

Number of citations of the paper that reports this interaction (PubMedID 8422437)
0

Data Source:
HPRD (in vitro)

		CR1	C4A
Description		complement C3b/C4b receptor 1 (Knops blood group)	complement C4A (Chido/Rodgers blood group)
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GO Annotations	Cellular Component	Extracellular Space Cytoskeleton Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Axon Dendrite Cell Projection Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Virus Receptor Activity Complement Binding Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Receptor Activity Complement Component C3b Receptor Activity Protein Binding	Complement Binding Complement Component C1q Complex Binding Antigen Binding Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes T Cell Mediated Immunity Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity ATP Export	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs			Human immunoglobulin G
Diseases			Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Alzheimer's disease ( 21460840 31473137 19734903) Alzheimer's disease (late onset) ( 28714976 30617256 24162737 21460841) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4	8 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 HSP90AA1 MASP2
Entrez ID		1378	720
HPRD ID		00398	00401
Ensembl ID		ENSG00000203710	ENSG00000244731
Uniprot IDs		E9PDY4 P17927	P0C0L4
PDB IDs		1GKG 1GKN 1PPQ 2MCY 2MCZ 2Q7Z 5FO9	1HZF 5JPM 5JPN 5JTW 6YSQ 7B2M 7B2P 7B2Q
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Complement Activation Humoral Immune Response Symbiont Cell Surface Positive Regulation Of Immune System Process Immune Effector Process Regulation Of Complement Activation Activation Of Immune Response Defense Response Vertebrate Eye-specific Patterning Classical-complement-pathway C3/C5 Convertase Complex Cell Surface Innate Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Complement-mediated Synapse Pruning Regulation Of Immune System Process Defense Response To Symbiont Defense Response To Other Organism Immune System Process Complement Binding Positive Regulation Of Apoptotic Cell Clearance Regulation Of Immune Response Synapse Pruning Regulation Of Apoptotic Cell Clearance Response To Other Organism Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Neuron Remodeling Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Opsonization Response To External Biotic Stimulus Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Regulation Of Adaptive Immune Response Neuron Maturation Antigen Binding Endopeptidase Inhibitor Activity Positive Regulation Of Phagocytosis Virus Receptor Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Inflammatory Response Leukocyte Activation Positive Regulation Of Activation Of Membrane Attack Complex	Complement Receptor Activity Complement Receptor Mediated Signaling Pathway Complement Component C4b Binding Complement Component C5a Receptor Activity Activation Of Immune Response Complement Component C5a Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune System Process Response To Stress Regulation Of Neutrophil Chemotaxis Complement Activation, Classical Pathway Defense Response Regulation Of Neutrophil Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Granulocyte Chemotaxis Complement Activation Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Complement Component C3a Receptor Activity Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process CTP Binding DATP Binding Regulation Of Protein Catabolic Process Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Negative Regulation Of Blood Vessel Remodeling Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Extracellular Exosome Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cytokine Production Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cholesterol Import
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