CR1 and C4A

Number of citations of the paper that reports this interaction (PMID 8422437)
3

Data Source:
HPRD (in vitro)

		CR1	C4A
Gene Name		complement component (3b/4b) receptor 1 (Knops blood group)	complement component 4A (Rodgers blood group)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity	Complement Component C1q Binding Endopeptidase Inhibitor Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 19734903) Alzheimer's disease (late onset) ( 21460841) Erythrocyte sedimentation rate ( 21700265) Inflammatory biomarkers ( 22291609)	Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: C1QA C3 C4A CD55 CR2 FUT4	6 interactors: APC APOA2 C3AR1 C5AR2 CR1 CST3
Entrez ID		1378	720
HPRD ID		00398	00401
Ensembl ID		ENSG00000203710	ENSG00000244731
Uniprot IDs		E9PDY4 P17927	P0C0L4
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2Q7Z	1HZF 4FXG 4FXK
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Complement Activation Positive Regulation Of Immune Response Regulation Of Humoral Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Immune Response Regulation Of Immune System Process Defense Response Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Phagocytosis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Phagocytosis Protein Metabolic Process Positive Regulation Of Endocytosis Response To Stress Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Negative Regulation Of Catalytic Activity CD4-positive, Alpha-beta T Cell Cytokine Production Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Protein Metabolic Process Complement Receptor Mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity L-fucose Catabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Maternal Process Involved In Parturition T Cell Cytokine Production Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Respiratory Burst Negative Regulation Of Proteolysis	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Defense Response Response To Stress Negative Regulation Of Catalytic Activity Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Negative Regulation Of Cytokine Secretion Regulation Of Granulocyte Chemotaxis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Immune System Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Cholesterol Transporter Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Protein Secretion Regulation Of Cell Migration Regulation Of Leukocyte Migration Regulation Of Cell Motility Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Cytokine Secretion Regulation Of Chemotaxis Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Complement Activation, Alternative Pathway Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Protein Localization Negative Regulation Of Secretion By Cell Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Collagen Catabolic Process Regulation Of Cholesterol Import Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Immune Response Regulation Of Behavior Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Extracellular Matrix Organization
Tagcloud ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable	alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Difference) ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable	alleles antitopoisomerase backgrounds c4aq0 c4b c4bq0 carried complement contribution diffuse dr drb1 electrophoresis genetical genotyping hla immunoblotting immunofixation japanese pc positivity q0 reflected scl scleroderma ssc sscp subgroup typing
Tagcloud (Intersection) ?