TIMP4 and MMP2

Number of citations of the paper that reports this interaction (PMID 9182583)
16

Data Source:
HPRD (in vitro)

		TIMP4	MMP2
Gene Name		TIMP metallopeptidase inhibitor 4	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Sarcomere	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Protease Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Central Nervous System Development Biological_process Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Lipopolysaccharide Response To Cytokine Response To Drug Ovulation Cycle Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs			Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MMP14 MMP2	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7079	4313
HPRD ID		03557	00386
Ensembl ID		ENSG00000157150	ENSG00000087245
Uniprot IDs		Q99727	P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Formation Of Primary Germ Layer Gastrulation Skeletal System Morphogenesis Ossification Response To Hypoxia Angiogenesis Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Morphogenesis Blood Vessel Development Vasculature Development Skeletal System Development Astrocyte Cell Migration Intramembranous Ossification Chondrocyte Proliferation Embryonic Morphogenesis Bone Trabecula Formation Blood Vessel Maturation Craniofacial Suture Morphogenesis Cardiovascular System Development Bone Trabecula Morphogenesis Endothelial Cell Proliferation Negative Regulation Of Focal Adhesion Assembly Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Response To Abiotic Stimulus Embryo Development Single Organism Reproductive Process Locomotion Face Morphogenesis Negative Regulation Of Cell-matrix Adhesion Reproductive Process Head Morphogenesis Endochondral Ossification Regulation Of Focal Adhesion Assembly Trabecula Morphogenesis Movement Of Cell Or Subcellular Component Face Development Proteolysis Negative Regulation Of Cell-substrate Adhesion Body Morphogenesis Regulation Of Cell Junction Assembly	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra coro2a cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 top2a tp53ink1 tusc5 tuscapital unmethylated	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra coro2a cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 top2a tp53ink1 tusc5 tuscapital unmethylated	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?