TIMP4 and MMP2

Number of citations: 0 (PubMedID 12374789)
Data Source: HPRD (in vitro)

		TIMP4	MMP2
Name		TIMP metallopeptidase inhibitor 4	matrix metallopeptidase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix
	Molecular Function	Enzyme Inhibitor Activity Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Notch Signaling Pathway Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		None	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		None	Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases		None	Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Blood protein levels ( 30072576 ) Triglyceride levels ( 32203549 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Heel bone mineral density ( 30598549 ) Lack of premeditation ( 30718321 ) Refractive error ( 32231278 )
Interacting Genes		4 interacting genes: CORO1C ERRFI1 MMP14 MMP2	40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7079	4313
HPRD ID		03557	00386
Ensembl ID		ENSG00000157150	ENSG00000087245
Uniprot IDs		Q99727	P08253
PDB IDs		Not available	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
GO Terms Enriched among Interactors		Cell Migration Macrophage Chemotaxis Chondrocyte Proliferation Negative Regulation Of Focal Adhesion Assembly Macrophage Migration Cell Motility Endodermal Cell Differentiation Negative Regulation Of Cell Adhesion Collagen Catabolic Process Negative Regulation Of Cell-matrix Adhesion Embryo Implantation Ovarian Follicle Development Extracellular Matrix Disassembly Sarcomere Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Estrogen Negative Regulation Of Cell-substrate Adhesion Collagen Metabolic Process Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Cell-substrate Junction Organization Negative Regulation Of Kinase Activity Tissue Remodeling Endopeptidase Activity Metalloendopeptidase Activity Response To Hormone Enzyme-linked Receptor Protein Signaling Pathway Mononuclear Cell Migration Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Negative Regulation Of Protein Phosphorylation Response To Estradiol Skeletal System Morphogenesis Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Ossification Myeloid Leukocyte Migration Metallopeptidase Activity Ameboidal-type Cell Migration Leukocyte Chemotaxis Regulation Of Cell Adhesion Serine-type Endopeptidase Activity Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Developmental Process Involved In Reproduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Epithelial Cell Proliferation	Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis