ITGAM and CFH

Number of citations of the paper that reports this interaction (PMID 9558116)
23

Data Source:
HPRD (in vitro)

		ITGAM	CFH
Gene Name		integrin, alpha M (complement component 3 receptor 3 subunit)	complement factor H
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Protein-Protein Interactions		18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1	16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID		3684	3075
HPRD ID		00411	00601
Ensembl ID		ENSG00000169896	ENSG00000000971
Uniprot IDs		P11215	F8WDX4 P08603
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76	1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade	Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow
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