ITGAM and CFH

Number of citations of the paper that reports this interaction (PubMedID 9558116)
0

Data Source:
HPRD (in vitro)

		ITGAM	CFH
Description		integrin subunit alpha M	complement factor H
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Signaling Receptor Activity Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding	Complement Component C3b Binding Protein Binding Heparin Binding Identical Protein Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Microglial Cell Activation Immune System Process Complement Receptor Mediated Signaling Pathway Response To Ischemia Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Metabolic Process Ectodermal Cell Differentiation Forebrain Development Response To Estradiol Positive Regulation Of Superoxide Anion Generation Heterotypic Cell-cell Adhesion Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Gram-positive Bacterium Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Microglial Cell Mediated Cytotoxicity Response To Curcumin	Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Innate Immune Response Regulation Of Complement-dependent Cytotoxicity
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Regulation of Complement cascade
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 24871463 32771030 28714469 27399966 26606652 26502338 18204098 23273568 21408207 19838195 19165918 18204446) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 32741009 23577725 23536807 23455636 23326517 22694956 21665990 20861866 15761122 20385826) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Aspartate aminotransferase levels ( 33547301) Chronic central serous retinopathy ( 30073298 30480742) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Complement factor H binding to malondialdehyde ( 32321835) Complement factor H levels ( 34260947) Complement factor H-related protein 2 levels ( 34260947) Complement factor H-related protein 3 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) Complement factor H-related protein 5 levels ( 34260947) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Fuchs's corneal dystrophy ( 28358029) Liver enzyme levels (alanine transaminase) ( 33972514) Matrix metalloproteinase-8 levels ( 29212897) Meningococcal disease ( 20694013) Neovascular age-related macular degeneration ( 28703135) Nephropathy ( 21399633) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Rheumatic heart disease ( 34106200) Serum C3d:C3 ratio (systemic complement activation) ( 29398083) Sub-foveal choroidal thickness ( 29844195) Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		56 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 GPX8 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35H1 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2	19 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 DYRK1A EP300 GRB2 ITGAM LCOR PTX3 RSPH1 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID		3684	3075
HPRD ID		00411	00601
Ensembl ID		ENSG00000169896	ENSG00000000971
Uniprot IDs		P11215	A0A0D9SG88 P08603
PDB IDs		1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW 7AKK 7P2D 7USL 7USM 8CE6 8CE9 8VOH 8VOI	1HAQ 1HCC 1HFH 1HFI 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG 6ZH1 7WKI 7ZJM 9F7I
Enriched GO Terms of Interacting Partners?		Membrane External Side Of Plasma Membrane Regulation Of Cellular Extravasation Adhesion Of Symbiont To Host Cell Virion Attachment To Host Cell Integrin Binding Adhesion Of Symbiont To Host Positive Regulation Of Cellular Extravasation Endoplasmic Reticulum Membrane Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Cell-cell Adhesion ICAM-3 Receptor Activity Peptide Antigen Transport Cell Surface Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Apoptotic Signaling Pathway Protein Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Receptor-mediated Virion Attachment To Host Cell Heterotypic Cell-cell Adhesion Intracellular Transport Of Virus Endoplasmic Reticulum Host Cell Serine-type Endopeptidase Complex Virion Binding Plasma Membrane Cell Adhesion Complement Component C3b Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Blood Microparticle	Immune Response Immune System Process Defense Response Defense Response To Other Organism Defense Response To Symbiont Opsonization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Immune Effector Process Vertebrate Eye-specific Patterning Response To External Biotic Stimulus Activation Of Immune Response Positive Regulation Of Immune System Process Complement-mediated Synapse Pruning Regionalization Extracellular Space Regulation Of Reactive Oxygen Species Metabolic Process Response To Stress Regulation Of Immune System Process Transcription Corepressor Binding Complement Activation Positive Regulation Of Ossification Complement Component C1q Complex Binding Positive Regulation Of Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Immune Response Innate Immune Response Synapse Pruning Virion Binding Pattern Specification Process Positive Regulation Of Immune Response Complement Component C3b Binding Regulation Of Multicellular Organismal Development Complement Receptor Mediated Signaling Pathway Response To Yeast Immune Response-activating Cell Surface Receptor Signaling Pathway Humoral Immune Response Low-density Lipoprotein Particle Binding Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Inflammatory Response Regulation Of Superoxide Anion Generation
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