ITGAM and JAM3

Number of citations of the paper that reports this interaction (PMID 12208882)
65

Data Source:
HPRD (in vivo, in vitro)

		ITGAM	JAM3
Gene Name		integrin, alpha M (complement component 3 receptor 3 subunit)	junctional adhesion molecule 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Extracellular Space Golgi Apparatus Plasma Membrane Tight Junction Integral Component Of Membrane Desmosome Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone
	Molecular Function	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell-matrix Adhesion Spermatid Development Blood Coagulation Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Myelination Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System	Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1	6 interactors: F2RL2 ITGAM ITGAX JAM2 PICK1 TJP1
Entrez ID		3684	83700
HPRD ID		00411	06042
Ensembl ID		ENSG00000169896	ENSG00000166086
Uniprot IDs		P11215	Q9BX67
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Cell-cell Signaling Involved In Cell-cell Junction Organization Glial Cell Development Response To Stress Integrin-mediated Signaling Pathway Response To External Stimulus Microglia Development Cell Migration Glial Cell Differentiation Response To Magnetism Cell Motility Ectodermal Cell Differentiation Gliogenesis Establishment Of Endothelial Intestinal Barrier Response To Stimulus DNA Methylation Involved In Embryo Development Cell Adhesion Dendritic Spine Maintenance Signal Transduction Locomotion Neuronal Ion Channel Clustering Thrombin Receptor Signaling Pathway Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Vascular Permeability Negative Regulation Of Actin Nucleation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Movement Of Cell Or Subcellular Component Long Term Synaptic Depression Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Receptor Internalization Macrophage Differentiation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Heterotypic Cell-cell Adhesion DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Ectoderm Development Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?