ITGAM and DKK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ITGAM	DKK4
Description		integrin subunit alpha M	dickkopf Wnt signaling pathway inhibitor 4
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Extracellular Space
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Signaling Receptor Activity Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Microglial Cell Activation Immune System Process Complement Receptor Mediated Signaling Pathway Response To Ischemia Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Metabolic Process Ectodermal Cell Differentiation Forebrain Development Response To Estradiol Positive Regulation Of Superoxide Anion Generation Heterotypic Cell-cell Adhesion Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Gram-positive Bacterium Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Microglial Cell Mediated Cytotoxicity Response To Curcumin	Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Hair Follicle Placode Formation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 24871463 32771030 28714469 27399966 26606652 26502338 18204098 23273568 21408207 19838195 19165918 18204446) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		56 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 GPX8 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35H1 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2	3 interacting genes: GIMAP5 ITGAM TSPO2
Entrez ID		3684	27121
HPRD ID		00411	05660
Ensembl ID		ENSG00000169896	ENSG00000104371
Uniprot IDs		P11215	Q9UBT3
PDB IDs		1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW 7AKK 7P2D 7USL 7USM 8CE6 8CE9 8VOH 8VOI	5O57
Enriched GO Terms of Interacting Partners?		Membrane External Side Of Plasma Membrane Regulation Of Cellular Extravasation Adhesion Of Symbiont To Host Cell Virion Attachment To Host Cell Integrin Binding Adhesion Of Symbiont To Host Positive Regulation Of Cellular Extravasation Endoplasmic Reticulum Membrane Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Cell-cell Adhesion ICAM-3 Receptor Activity Peptide Antigen Transport Cell Surface Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Apoptotic Signaling Pathway Protein Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Receptor-mediated Virion Attachment To Host Cell Heterotypic Cell-cell Adhesion Intracellular Transport Of Virus Endoplasmic Reticulum Host Cell Serine-type Endopeptidase Complex Virion Binding Plasma Membrane Cell Adhesion Complement Component C3b Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Blood Microparticle	ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation ERBB2-ERBB4 Signaling Pathway Integrin Binding Endocardial Cell Differentiation Nickel Cation Binding Integrin AlphaM-beta2 Complex Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Ectodermal Cell Differentiation 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Protein Autophosphorylation ERBB4-ERBB4 Signaling Pathway Regulation Of Neutrophil Degranulation Response To Gram-positive Bacterium Enucleate Erythrocyte Differentiation Activation Of Protein Kinase B Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Synapse Pruning Cardiac Muscle Cell Myoblast Differentiation Complement Component C3b Binding Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Complement Receptor Mediated Signaling Pathway Protein Tyrosine Kinase Activator Activity Stem Cell Development Mammary Gland Development Positive Regulation Of Heart Growth Endothelial Cell Differentiation Heart Trabecula Morphogenesis Cardiac Muscle Cell Differentiation Myoblast Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peripheral Nervous System Development Negative Regulation Of Striated Muscle Cell Apoptotic Process Neural Crest Cell Development ERBB2 Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Secretion
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