ITGAM and CLEC4M

Number of citations of the paper that reports this interaction (PubMedID 16246332)
0

Data Source:
HPRD (in vitro)

		ITGAM	CLEC4M
Description		integrin subunit alpha M	C-type lectin domain family 4 member M
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Host Cell
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Signaling Receptor Activity Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding ICAM-3 Receptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Antigen Binding Virion Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Microglial Cell Activation Immune System Process Complement Receptor Mediated Signaling Pathway Response To Ischemia Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Metabolic Process Ectodermal Cell Differentiation Forebrain Development Response To Estradiol Positive Regulation Of Superoxide Anion Generation Heterotypic Cell-cell Adhesion Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Gram-positive Bacterium Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Microglial Cell Mediated Cytotoxicity Response To Curcumin	Adaptive Immune Response Immune System Process Endocytosis Immune Response Leukocyte Cell-cell Adhesion Cell-cell Recognition Virion Attachment To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Innate Immune Response Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Peptide Antigen Transport Intracellular Transport Of Virus
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	RSV-host interactions
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 24871463 32771030 28714469 27399966 26606652 26502338 18204098 23273568 21408207 19838195 19165918 18204446) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Lipoprotein (a) levels ( 33730874) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) vWF levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 GPX8 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35H1 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2	6 interacting genes: CD209 ICAM3 IFT20 ITGAM PLPP6 SNCA
Entrez ID		3684	10332
HPRD ID		00411	12060
Ensembl ID		ENSG00000169896	ENSG00000104938
Uniprot IDs		P11215	A0A7P0MMK7 Q9H2X3
PDB IDs		1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW 7AKK 7P2D 7USL 7USM 8CE6 8CE9 8VOH 8VOI	1K9J 1SL6 1XAR 1XPH 3JQH 8RCY
Enriched GO Terms of Interacting Partners?		Membrane External Side Of Plasma Membrane Regulation Of Cellular Extravasation Adhesion Of Symbiont To Host Cell Virion Attachment To Host Cell Integrin Binding Adhesion Of Symbiont To Host Positive Regulation Of Cellular Extravasation Endoplasmic Reticulum Membrane Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Cell-cell Adhesion ICAM-3 Receptor Activity Peptide Antigen Transport Cell Surface Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Apoptotic Signaling Pathway Protein Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Receptor-mediated Virion Attachment To Host Cell Heterotypic Cell-cell Adhesion Intracellular Transport Of Virus Endoplasmic Reticulum Host Cell Serine-type Endopeptidase Complex Virion Binding Plasma Membrane Cell Adhesion Complement Component C3b Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Blood Microparticle	Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Endocytosis Import Into Cell Regulation Of Dopamine Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Vesicle-mediated Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Macrophage Activation Positive Regulation Of Exocytosis Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission B Cell Adhesion Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Cell-cell Adhesion Response To External Biotic Stimulus Integrin AlphaM-beta2 Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Opsin Transport Intraciliary Transport Particle Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Neutrophil Degranulation Response To Curcumin Vertebrate Eye-specific Patterning Myeloid Leukocyte Activation Regulation Of Immune System Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Cell Activation Negative Regulation Of Chaperone-mediated Autophagy Peptide Antigen Transport Kinociliary Basal Body Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Integrin Binding Positive Regulation Of Microglial Cell Mediated Cytotoxicity Complement-mediated Synapse Pruning Regulation Of Serotonin Uptake Opsin Binding Receptor-mediated Endocytosis
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