FCER1G and FAM209A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCER1G	FAM209A
Description		Fc epsilon receptor Ig	family with sequence similarity 209 member A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Fc-epsilon Receptor I Complex Fc-gamma Receptor III Complex Tertiary Granule Membrane Plasma Membrane Protein Complex Ficolin-1-rich Granule Membrane	Nucleus Nuclear Inner Membrane Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Immune Response Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Spermatogenesis Cell Differentiation
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen
Drugs		Benzylpenicilloyl polylysine
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 30929738 31361310 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 32888494)	Heschl's gyrus morphology ( 25130324)
Interacting Genes		83 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 CYP4F2 DEFB127 DGAT2L6 EBP FA2H FAM209A FAXDC2 FCER1A FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL NCR1 NCR3 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 RUSF1 SEC22B SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	258 interacting genes: ADGRE2 ADIPOQ AGTRAP AIG1 ALG8 ANKRD46 APMAP APOC3 APOD APOL2 APOL3 AQP1 AQP2 AQP3 ARLN ARV1 ASGR1 ATP13A1 B4GALNT2 BDNF BET1 BIK BMP10 BNIP2 BNIP3 BTN2A2 C11orf24 C14orf180 C1GALT1 C2 C3orf52 CANT1 CCL4L2 CD53 CD59 CD81 CDIPT CDS1 CDS2 CLCA4 CLDN19 CLDN2 CLDN4 CLDND2 CLEC4G CLN6 CMTM7 CNIH1 CNPY3 COL4A5 COL8A2 COMT CTRL CTSA CTXN3 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 DEFB121 DEFB128 DNAJC30 DOLK EBP EMC6 EMD ENTPD3 EOGT ERG28 ERMP1 FA2H FAM20B FAM3C FATE1 FCER1G FDFT1 FIS1 FUNDC2 FXYD3 FXYD6 GAST GET3 GHITM GIMAP1 GIMAP5 GJB2 GKN1 GKN2 GOSR2 GPR108 GPR151 GPR152 GPR37L1 GYPA HACD2 HHATL HMOX1 HMOX2 HTATIP2 IGFBP5 INSIG2 JAGN1 KIR2DL3 LAT LHFPL5 LPAR3 LRP10 MAL MARCHF2 MFF MFSD6 MGLL MIP MMD MMD2 MS4A1 MS4A13 MYADM MYADML2 NAPB NAT8 NCR3 NINJ2 NKG7 NRM NXPE3 OLFM4 ORMDL1 ORMDL3 OTOR PAQR7 PEDS1-UBE2V1 PEX16 PGAP2 PGLYRP3 PLLP PLN PLP1 PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 PTCH1 RHAG RPRM RTP2 RUSF1 S100A2 SACM1L SCARF1 SCD SCGB1D1 SCRG1 SEC22A SEC22B SEC61G SELENOK SEMA6C SERP1 SFTPC SLC13A3 SLC1A1 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC35E3 SLC35G2 SLC38A7 SLC39A2 SLC41A1 SLC52A2 SLC7A14 SMAGP SMCO4 SMIM1 SNORC STATH STRIT1 STX12 STX1B STX3 STX5 STX8 SYNGR1 SYT15 SYT15B TECR TEX264 TF TFRC THBD THSD7B TM6SF2 TMBIM6 TMEM100 TMEM107 TMEM11 TMEM120A TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM236 TMEM239 TMEM243 TMEM254 TMEM42 TMEM43 TMEM47 TMEM50B TMEM60 TMEM65 TMEM72 TMEM79 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TNF TNFRSF10C TNMD TRAF3IP3 TRAM1L1 TRARG1 TREX1 TSPAN2 TSPAN33 TSPAN7 TSPO TWSG1 UBE2J1 UBIAD1 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1 VMP1 VSTM1 WFDC2 WFS1 YIPF4 YIPF6 ZFPL1
Entrez ID		2207	200232
HPRD ID		00916	18536
Ensembl ID		ENSG00000158869	ENSG00000124103
Uniprot IDs		P30273	Q5JX71
PDB IDs		7Q5T 8YVU 8YWA
Enriched GO Terms of Interacting Partners?		Membrane Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Endoplasmic Reticulum Membrane Protein Binding Monoatomic Ion Transport Transmembrane Transport Hypersensitivity Immune Response-regulating Signaling Pathway Regulation Of Platelet Activation Amino Acid Transmembrane Transport Plasma Membrane Mitochondrial Membrane Acute Inflammatory Response To Antigenic Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway IgG Receptor Activity Amino Acid Transport Endoplasmic Reticulum Regulation Of Tumor Necrosis Factor Production Organic Cation Transport Fc-epsilon Receptor Signaling Pathway Antibody-dependent Cellular Cytotoxicity Monoatomic Cation Transport Zinc Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Zinc Ion Transport Metal Ion Transport Lipid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Low-affinity IgG Receptor Activity Immune Receptor Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Monoatomic Ion Transmembrane Transporter Activity Inflammatory Response To Antigenic Stimulus IgG Binding COPII-coated ER To Golgi Transport Vesicle Monoatomic Ion Transmembrane Transport Immunoglobulin Mediated Immune Response Regulation Of Cytokine Production Involved In Immune Response Serine Import Into Mitochondrion B Cell Mediated Immunity Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Organic Anion Transport Neutral Amino Acid Transport Regulation Of Secretion Nuclear Inner Membrane Inflammatory Response Follicular B Cell Differentiation	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Plasma Membrane SNARE Complex Golgi Apparatus Chemical Homeostasis Golgi Membrane Membrane Organization Vesicle Fusion Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Response To Mercury Ion Organelle Membrane Fusion Membrane Fusion Organelle Fusion Lipid Metabolic Process Localization Within Membrane Cholesterol Binding Multicellular Organismal-level Chemical Homeostasis Establishment Of Protein Localization To Membrane Lipid Biosynthetic Process Intracellular Chemical Homeostasis Vesicle-mediated Transport Sterol Biosynthetic Process Establishment Of Protein Localization Water Channel Activity SNARE Binding Membrane Docking Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Protein Localization To Membrane Ankyrin-1 Complex Glycerol Transmembrane Transport Paracellular Transport Nuclear Inner Membrane Sterol Metabolic Process Response To Bacterium Renal Water Transport Renal Water Homeostasis Intracellular Monoatomic Ion Homeostasis Heme Metabolic Process Protein Localization To Cell Periphery Organelle Localization By Membrane Tethering Glycerol Transmembrane Transporter Activity Phosphatidate Cytidylyltransferase Activity Cholesterol Biosynthetic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity
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