FCER1G and NCR1

Number of citations of the paper that reports this interaction (PMID 10049942)
61

Data Source:
HPRD (in vivo)

		FCER1G	NCR1
Gene Name		Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	natural cytotoxicity triggering receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex	Integral Component Of Plasma Membrane SWI/SNF Complex
	Molecular Function	Protein Binding IgE Receptor Activity IgE Binding IgG Binding	Receptor Signaling Protein Activity
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Protein Localization To Plasma Membrane	Cellular Defense Response Signal Transduction Natural Killer Cell Activation Intracellular Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Platelet Adhesion to exposed collagen FCERI mediated NF-kB activation GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall Innate Immune System
Drugs		Benzylpenicilloyl Polylysine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: FCER1A FCGR3A GP6 KIR2DL4 LYN NCR1 PLCG2 SYK	3 interactors: CD247 CD59 FCER1G
Entrez ID		2207	9437
HPRD ID		00916	05167
Ensembl ID		ENSG00000158869	ENSG00000189430
Uniprot IDs		P30273	O76036
PDB IDs			1OLL 1P6F
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Positive Regulation Of Interleukin-3 Biosynthetic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Mast Cell Activation B Cell Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Response To Stress Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Platelet Activation Immune System Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune Response Serotonin Secretion Phagocytosis Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Ammonium Transport Serotonin Transport Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Immune System Process Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Signaling Leukocyte Activation Regulation Of Platelet Aggregation Cell Communication Regulation Of Exocytosis Leukocyte Activation Involved In Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Body Fluid Levels Immune Response Leukotriene Biosynthetic Process Wound Healing Monoamine Transport	Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Type III Hypersensitivity Negative Regulation Of Activation Of Membrane Attack Complex Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Phagocytosis Fc Receptor Signaling Pathway Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Serotonin Secretion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Immune System Process Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Lymphocyte Activation Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Blood Coagulation Hemostasis Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Complement Activation Phagocytosis, Engulfment Positive Regulation Of Mast Cell Activation Regulation Of Body Fluid Levels Wound Healing Regulation Of Cell Adhesion Positive Regulation Of Immune Response Endocytosis
Tagcloud ?			adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncrs nk nkp46 partly proto ral rala ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Difference) ?			adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncrs nk nkp46 partly proto ral rala ralb recognition recognize regressions remarkable retrovirally termed
Tagcloud (Intersection) ?