FCER1G and CLEC4E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCER1G	CLEC4E
Description		Fc epsilon receptor Ig	C-type lectin domain family 4 member E
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Fc-epsilon Receptor I Complex Fc-gamma Receptor III Complex Tertiary Granule Membrane Plasma Membrane Protein Complex Ficolin-1-rich Granule Membrane	Phagocytic Cup Plasma Membrane External Side Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Cell Projection
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding Protein Homodimerization Activity	Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Metal Ion Binding Glycolipid Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Immune Response Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway T Cell Differentiation Involved In Immune Response Immune System Process Immune Response-regulating Signaling Pathway Immune Response Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Antifungal Innate Immune Response
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	Dectin-2 family Dectin-2 family
Drugs		Benzylpenicilloyl polylysine	Cholesterol
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 30929738 31361310 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 32888494)	Takayasu arteritis ( 25604533)
Interacting Genes		83 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 CYP4F2 DEFB127 DGAT2L6 EBP FA2H FAM209A FAXDC2 FCER1A FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL NCR1 NCR3 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 RUSF1 SEC22B SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	4 interacting genes: CXCL9 FAM3C FCER1G NKG7
Entrez ID		2207	26253
HPRD ID		00916	13075
Ensembl ID		ENSG00000158869	ENSG00000166523
Uniprot IDs		P30273	F5H5X7 Q9ULY5
PDB IDs		7Q5T 8YVU 8YWA	3WH2 3WH3
Enriched GO Terms of Interacting Partners?		Membrane Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Endoplasmic Reticulum Membrane Protein Binding Monoatomic Ion Transport Transmembrane Transport Hypersensitivity Immune Response-regulating Signaling Pathway Regulation Of Platelet Activation Amino Acid Transmembrane Transport Plasma Membrane Mitochondrial Membrane Acute Inflammatory Response To Antigenic Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway IgG Receptor Activity Amino Acid Transport Endoplasmic Reticulum Regulation Of Tumor Necrosis Factor Production Organic Cation Transport Fc-epsilon Receptor Signaling Pathway Antibody-dependent Cellular Cytotoxicity Monoatomic Cation Transport Zinc Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Zinc Ion Transport Metal Ion Transport Lipid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Low-affinity IgG Receptor Activity Immune Receptor Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Monoatomic Ion Transmembrane Transporter Activity Inflammatory Response To Antigenic Stimulus IgG Binding COPII-coated ER To Golgi Transport Vesicle Monoatomic Ion Transmembrane Transport Immunoglobulin Mediated Immune Response Regulation Of Cytokine Production Involved In Immune Response Serine Import Into Mitochondrion B Cell Mediated Immunity Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Organic Anion Transport Neutral Amino Acid Transport Regulation Of Secretion Nuclear Inner Membrane Inflammatory Response Follicular B Cell Differentiation	Granulocyte Migration Defense Response Neutrophil Chemotaxis Myeloid Leukocyte Migration IgE Receptor Activity Regulated Exocytosis Defense Response To Other Organism Leukocyte Degranulation Granulocyte Chemotaxis Neutrophil Migration Lymphocyte Mediated Immunity Defense Response To Symbiont Inflammatory Response Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Leukocyte Chemotaxis Positive Regulation Of Type I Hypersensitivity Leukocyte Mediated Immunity Myeloid Leukocyte Differentiation Fc-epsilon Receptor I Complex Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Inflammatory Response Positive Regulation Of Type III Hypersensitivity Cell Killing Cell Chemotaxis Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Exocytosis Cytokine Activity Cytolytic Granule Membrane Response To Other Organism Leukocyte Migration Response To Stress Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process CXCR3 Chemokine Receptor Binding Immune Response Myeloid Cell Differentiation Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Natural Killer Cell Degranulation Immune Response To Tumor Cell Response To External Biotic Stimulus Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation T Cell Activation
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