TG and CTSD

Number of citations of the paper that reports this interaction (PubMedID 1939080)
0

Data Source:
HPRD (in vitro)

		TG	CTSD
Description		thyroglobulin	cathepsin D
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Cytosol Endosome Membrane Extracellular Matrix Endosome Lumen Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding	Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic-type Peptidase Activity
	Biological Process	Thyroid Hormone Generation Signal Transduction Iodide Transport Thyroid Gland Development Regulation Of Myelination Thyroid Hormone Metabolic Process Hormone Biosynthetic Process	Autophagosome Assembly Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Insulin Receptor Recycling Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Execution Phase Of Apoptosis Insulin Catabolic Process
Pathways			Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Insulin receptor recycling Estrogen-dependent gene expression
Drugs			S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 34103634) Autoimmune thyroid disease ( 32581359) Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Graves' disease ( 23612905) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Temperament ( 22832960) Thyroid stimulating hormone levels ( 30367059) Vitiligo ( 27723757)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)
Interacting Genes		10 interacting genes: APCS ASGR1 CANX CRYM CTSD CTSL HSP90B1 HSPA5 LRP2 P4HB	25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG
Entrez ID		7038	1509
HPRD ID		01782	00291
Ensembl ID		ENSG00000042832	ENSG00000117984
Uniprot IDs		P01266	P07339 V9HWI3
PDB IDs		6SCJ 7B75	1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9
Enriched GO Terms of Interacting Partners?		Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Chaperone Complex Protein Folding Extracellular Exosome Melanosome Unfolded Protein Binding Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress Calcium Ion Binding Protein Catabolic Process Proteolysis Endoplasmic Reticulum Lumen ERAD Pathway Hormone Binding Insulin Metabolic Process Endocytic Vesicle Lumen Endosome Lumen Endocytosis Carbohydrate Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macromolecule Catabolic Process Hormone Metabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ATP-dependent Protein Folding Chaperone Peptide Hormone Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Vesicle-mediated Transport Signaling Receptor Ligand Precursor Processing Catabolic Process Import Into Cell Antigen Processing And Presentation Of Exogenous Antigen Proteolysis Involved In Protein Catabolic Process Extracellular Region Delta1-piperideine-2-carboxylate Reductase Activity Thiomorpholine-carboxylate Dehydrogenase Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Protein Folding Chaperone Regulation Of Protein Folding In Endoplasmic Reticulum Antigen Processing And Presentation Of Peptide Antigen Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Maintenance Of Location In Cell Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Asialoglycoprotein Receptor Activity External Side Of Plasma Membrane Endoplasmic Reticulum Aspartic-type Peptidase Activity	Extracellular Space Extracellular Region Endoplasmic Reticulum Lumen Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Insulin-like Growth Factor II Binding Regulation Of MAPK Cascade Cognition Regulation Of Protein Metabolic Process Protease Binding Insulin-like Growth Factor Binding Regulation Of Phosphorus Metabolic Process Learning Or Memory Type B Pancreatic Cell Proliferation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of Synaptic Plasticity Amyloid Fibril Formation Response To Cytokine Regulation Of Cellular Component Organization Microglial Cell Activation Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Glucose Metabolic Process Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Regulation Of Signaling Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cell-cell Signaling Positive Regulation Of Intracellular Signal Transduction Peptidase Inhibitor Activity Main Axon Cellular Response To Oxygen-containing Compound Signaling Negative Regulation Of Protein Catabolic Process Ficolin-1-rich Granule Lumen Cell Communication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of MAPK Cascade Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteolysis
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