TG and CRYM

Number of citations of the paper that reports this interaction (PubMedID 9328354)
0

Data Source:
BioGRID (pull down)

		TG	CRYM
Description		thyroglobulin	crystallin mu
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Cytoplasm Mitochondrion Peroxisomal Matrix Cytosol Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding	Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Hormone Binding Protein Homodimerization Activity Delta1-piperideine-2-carboxylate Reductase Activity Thiomorpholine-carboxylate Dehydrogenase Activity NADP Binding Thyroid Hormone Binding
	Biological Process	Thyroid Hormone Generation Signal Transduction Iodide Transport Thyroid Gland Development Regulation Of Myelination Thyroid Hormone Metabolic Process Hormone Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Lysine Catabolic Process Sensory Perception Of Sound Thyroid Hormone Metabolic Process Thyroid Hormone Transport
Pathways			Lysine catabolism
Drugs			NRP409
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 34103634) Autoimmune thyroid disease ( 32581359) Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Graves' disease ( 23612905) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Temperament ( 22832960) Thyroid stimulating hormone levels ( 30367059) Vitiligo ( 27723757)	Pelvic organ prolapse ( 26545240)
Interacting Genes		10 interacting genes: APCS ASGR1 CANX CRYM CTSD CTSL HSP90B1 HSPA5 LRP2 P4HB	5 interacting genes: ADRB2 C7orf25 CDC37 TERF1 TG
Entrez ID		7038	1428
HPRD ID		01782	08831
Ensembl ID		ENSG00000042832	ENSG00000103316
Uniprot IDs		P01266	Q14894
PDB IDs		6SCJ 7B75	2I99
Enriched GO Terms of Interacting Partners?		Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Chaperone Complex Protein Folding Extracellular Exosome Melanosome Unfolded Protein Binding Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress Calcium Ion Binding Protein Catabolic Process Proteolysis Endoplasmic Reticulum Lumen ERAD Pathway Hormone Binding Insulin Metabolic Process Endocytic Vesicle Lumen Endosome Lumen Endocytosis Carbohydrate Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macromolecule Catabolic Process Hormone Metabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ATP-dependent Protein Folding Chaperone Peptide Hormone Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Vesicle-mediated Transport Signaling Receptor Ligand Precursor Processing Catabolic Process Import Into Cell Antigen Processing And Presentation Of Exogenous Antigen Proteolysis Involved In Protein Catabolic Process Extracellular Region Delta1-piperideine-2-carboxylate Reductase Activity Thiomorpholine-carboxylate Dehydrogenase Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Protein Folding Chaperone Regulation Of Protein Folding In Endoplasmic Reticulum Antigen Processing And Presentation Of Peptide Antigen Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Maintenance Of Location In Cell Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Asialoglycoprotein Receptor Activity External Side Of Plasma Membrane Endoplasmic Reticulum Aspartic-type Peptidase Activity	Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Macroautophagy Beta2-adrenergic Receptor Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication HSP90-CDC37 Chaperone Complex Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Response To Psychosocial Stress Positive Regulation Of Autophagy Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Macroautophagy Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Iodide Transport Adrenergic Receptor Activity Nuclear Telomere Cap Complex Telomere Localization Meiotic Telomere Clustering Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Diet Induced Thermogenesis G-rich Strand Telomeric DNA Binding Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction T-circle Formation Telomeric Loop Disassembly Telomere Capping Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Multicellular Organism Growth Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Thyroid Hormone Generation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction DNA Binding, Bending
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