TG and P4HB

Number of citations of the paper that reports this interaction (PMID 10636893)
7

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		TG	P4HB
Gene Name		thyroglobulin	prolyl 4-hydroxylase, beta polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion Procollagen-proline 4-dioxygenase Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Carboxylic Ester Hydrolase Activity	Protein Disulfide Isomerase Activity Endopeptidase Activity Procollagen-proline 4-dioxygenase Activity Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Iodide Transport Thyroid Gland Development Regulation Of Myelination Thyroid Hormone Metabolic Process Hormone Biosynthetic Process	Response To Reactive Oxygen Species Protein Folding Proteolysis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Extracellular Matrix Organization Response To Endoplasmic Reticulum Stress Lipoprotein Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways			Lipoprotein metabolism Hedgehog ligand biogenesis Metabolism of lipids and lipoproteins Collagen formation Chylomicron-mediated lipid transport Processing-defective Hh variants abrogate ligand secretion Detoxification of Reactive Oxygen Species Lipid digestion, mobilization, and transport Signaling by Hedgehog Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Graves' disease ( 23612905) Temperament ( 22832960)
Protein-Protein Interactions		9 interactors: APCS ASGR1 CANX CTSD CTSL HSP90B1 HSPA5 LRP2 P4HB	17 interactors: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1L ERO1LB FEZ1 HNRNPD P4HA2 P4HA3 PRNP PTN TG UBQLN1 YWHAG
Entrez ID		7038	5034
HPRD ID		01782	07181
Ensembl ID		ENSG00000042832	ENSG00000185624
Uniprot IDs		P01266	B3KTQ9 B4DUA5 F5H8J2 P07237
PDB IDs			1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1
Enriched GO Terms of Interacting Partners?		Protein Folding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Response To Endoplasmic Reticulum Stress Endocytosis Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Vesicle-mediated Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Proteolysis Antigen Processing And Presentation Cellular Protein Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Folding In Endoplasmic Reticulum Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Extracellular Matrix Disassembly Immune System Process Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Toll-like Receptor Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Actin Rod Assembly Cerebellum Structural Organization Negative Regulation Of Exo-alpha-sialidase Activity Macrophage Apoptotic Process Cellular Response To Topologically Incorrect Protein Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Response To Unfolded Protein Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Catabolic Process Sequestering Of Calcium Ion Positive Regulation Of Innate Immune Response Negative Regulation Of Monocyte Differentiation Cellular Response To Extracellular Stimulus Innate Immune Response Myeloid Cell Apoptotic Process Catabolic Process	4-hydroxyproline Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Protein Maturation By Protein Folding Cellular Modified Amino Acid Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Peptidyl-proline Hydroxylation Protein Hydroxylation System Development Response To Endoplasmic Reticulum Stress Developmental Process Protein Trimerization Protein Maturation Endochondral Ossification Multicellular Organismal Development Anatomical Structure Development Skin Morphogenesis Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Cellular Response To Fluoride Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Alpha-amino Acid Metabolic Process Ossification Cellular Response To Organic Substance Biomineral Tissue Development Locomotion Response To Fluoride Tooth Eruption Cellular Response To Stimulus Endochondral Bone Morphogenesis Regulation Of Cellular Protein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Stimulus Axon Guidance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Amino Acid Response To Oxidative Stress Protein Oligomerization Cell Redox Homeostasis Bone Morphogenesis
Tagcloud ?		amplify aspiration checked cytological cytology deiodinase di diagnostically dii dilutions fine fnab fnabs ftc ie iodide iodothyronine isolation mentioned needle nis obtaining preparing rendered routinely smears suspicious symporter thyroglobulin thyroid	anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved
Tagcloud (Difference) ?		amplify aspiration checked cytological cytology deiodinase di diagnostically dii dilutions fine fnab fnabs ftc ie iodide iodothyronine isolation mentioned needle nis obtaining preparing rendered routinely smears suspicious symporter thyroglobulin thyroid	anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved
Tagcloud (Intersection) ?