TG and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 10049727)
0

Data Source:
HPRD (in vitro)

		TG	HSP90B1
Description		thyroglobulin	heat shock protein 90 beta family member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Thyroid Hormone Generation Signal Transduction Iodide Transport Thyroid Gland Development Regulation Of Myelination Thyroid Hormone Metabolic Process Hormone Biosynthetic Process	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane
Pathways			Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 34103634) Autoimmune thyroid disease ( 32581359) Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Graves' disease ( 23612905) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Temperament ( 22832960) Thyroid stimulating hormone levels ( 30367059) Vitiligo ( 27723757)	Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		10 interacting genes: APCS ASGR1 CANX CRYM CTSD CTSL HSP90B1 HSPA5 LRP2 P4HB	40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		7038	7184
HPRD ID		01782	01860
Ensembl ID		ENSG00000042832	ENSG00000166598
Uniprot IDs		P01266	P14625 V9HWP2
PDB IDs		6SCJ 7B75	4NH9 7ULL
Enriched GO Terms of Interacting Partners?		Protein Folding In Endoplasmic Reticulum Endoplasmic Reticulum Chaperone Complex Protein Folding Extracellular Exosome Melanosome Unfolded Protein Binding Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress Calcium Ion Binding Protein Catabolic Process Proteolysis Endoplasmic Reticulum Lumen ERAD Pathway Hormone Binding Insulin Metabolic Process Endocytic Vesicle Lumen Endosome Lumen Endocytosis Carbohydrate Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Macromolecule Catabolic Process Hormone Metabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ATP-dependent Protein Folding Chaperone Peptide Hormone Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Vesicle-mediated Transport Signaling Receptor Ligand Precursor Processing Catabolic Process Import Into Cell Antigen Processing And Presentation Of Exogenous Antigen Proteolysis Involved In Protein Catabolic Process Extracellular Region Delta1-piperideine-2-carboxylate Reductase Activity Thiomorpholine-carboxylate Dehydrogenase Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Protein Folding Chaperone Regulation Of Protein Folding In Endoplasmic Reticulum Antigen Processing And Presentation Of Peptide Antigen Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Maintenance Of Location In Cell Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Asialoglycoprotein Receptor Activity External Side Of Plasma Membrane Endoplasmic Reticulum Aspartic-type Peptidase Activity	Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding
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