TFAM and PNP

Number of citations of the paper that reports this interaction (PMID 12068295)
109

Data Source:
HPRD (in vitro)

		TFAM	PNP
Gene Name		transcription factor A, mitochondrial	purine nucleoside phosphorylase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Nucleoid	Intracellular Cytoplasm Cytosol Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding DNA Binding, Bending Heat Shock Protein Binding Poly(A) RNA Binding Mitochondrial Light Strand Promoter Sense Binding	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Drug Binding Phosphate Ion Binding
	Biological Process	DNA-dependent DNA Replication Chromatin Remodeling Regulation Of Transcription From RNA Polymerase I Promoter Transcription From Mitochondrial Promoter Transcription Initiation From Mitochondrial Promoter Organelle Organization Mitochondrion Organization Gene Expression Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Inosine Catabolic Process Purine Nucleotide Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Response To Drug Purine-containing Compound Salvage Small Molecule Metabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation Nucleobase-containing Small Molecule Metabolic Process Interleukin-2 Secretion
Pathways		Organelle biogenesis and maintenance Mitochondrial transcription initiation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Transcription from mitochondrial promoters Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	Purine catabolism Purine metabolism Metabolism of nucleotides Purine salvage
Drugs			Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-Deazainosine Guanosine Ribose-1-Phosphate 4\'-Deaza-1\'-Aza-2\'-Deoxy-1\'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol 3-Deoxyguanosine MT-Immucillin-H Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine 9-DEAZAINOSINE-2\',3\'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2\',3\'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2\',3\'-O-METHYLIDENEPHOSPHONATE
Diseases
GWAS		Height ( 23456168)
Protein-Protein Interactions		5 interactors: AGTRAP ARL6IP1 PNP TFB1M TFB2M	10 interactors: APLP1 CCDC90B LRIF1 NCALD RBM48 TFAM TFB2M TP53 UCHL5 ZHX1
Entrez ID		7019	4860
HPRD ID		02702	01247
Ensembl ID		ENSG00000108064
Uniprot IDs		E5KSU5 Q00059	P00491
PDB IDs		3FGH 3TMM 3TQ6	1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA
Enriched GO Terms of Interacting Partners?		RRNA Methylation RRNA Modification RNA Methylation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Inosine Catabolic Process Nicotinamide Riboside Catabolic Process RRNA Processing RRNA Metabolic Process Interleukin-2 Secretion Urate Biosynthetic Process RNA Modification Transcription Initiation From Mitochondrial Promoter Ribosome Biogenesis Angiotensin-activated Signaling Pathway Ribonucleoprotein Complex Biogenesis Interleukin-2 Production Transcription From Mitochondrial Promoter Urate Metabolic Process Purine Ribonucleoside Catabolic Process Mitochondrion Organization Methylation NcRNA Metabolic Process Regulation Of Appetite Purine-containing Compound Salvage NAD Biosynthetic Process Cytokine Secretion Purine Nucleotide Catabolic Process Purine Nucleobase Metabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation NAD Metabolic Process	Transcription Initiation From Mitochondrial Promoter Transcription From Mitochondrial Promoter RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrion Organization Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Helicase Activity Cellular Response To Norepinephrine Stimulus Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Brain Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Head Development Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Response To Norepinephrine Mitochondrial DNA Repair DNA-templated Transcription, Initiation Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Metabolic Process Central Nervous System Development ER Overload Response
Tagcloud ?		analogs apoptogenic biogenesis coded counterpart diminished dissipation doses her2high inducer innovation lowered mitocans mitochondrial mitochondrially mitoves mtdna replicated respiration succinate suppress suppresses targeted tocopheryl transcript transcripts unlike untargeted vitamin	adenylylimidodiphosphate altering amp analog anion anions atp channel cl closed conductance electrogenic flowed flux hidden hill lumen markov mv nonhydrolyzable pass rectification ruled sarcoplasmic sr substates unlikely voltage voltages
Tagcloud (Difference) ?		analogs apoptogenic biogenesis coded counterpart diminished dissipation doses her2high inducer innovation lowered mitocans mitochondrial mitochondrially mitoves mtdna replicated respiration succinate suppress suppresses targeted tocopheryl transcript transcripts unlike untargeted vitamin	adenylylimidodiphosphate altering amp analog anion anions atp channel cl closed conductance electrogenic flowed flux hidden hill lumen markov mv nonhydrolyzable pass rectification ruled sarcoplasmic sr substates unlikely voltage voltages
Tagcloud (Intersection) ?