PNP and NCALD

Number of citations of the paper that reports this interaction (PMID 11964161)
15

Data Source:
HPRD (in vitro, in vivo)

		PNP	NCALD
Gene Name		purine nucleoside phosphorylase	neurocalcin delta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytosol Cytoskeleton Extracellular Vesicular Exosome	Intracellular Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle Extracellular Vesicular Exosome
	Molecular Function	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Drug Binding Phosphate Ion Binding	Actin Binding Calcium Ion Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Inosine Catabolic Process Purine Nucleotide Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Response To Drug Purine-containing Compound Salvage Small Molecule Metabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation Nucleobase-containing Small Molecule Metabolic Process Interleukin-2 Secretion	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Vesicle-mediated Transport Calcium-mediated Signaling
Pathways		Purine catabolism Purine metabolism Metabolism of nucleotides Purine salvage	Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-Deazainosine Guanosine Ribose-1-Phosphate 4\'-Deaza-1\'-Aza-2\'-Deoxy-1\'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol 3-Deoxyguanosine MT-Immucillin-H Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine 9-DEAZAINOSINE-2\',3\'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2\',3\'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2\',3\'-O-METHYLIDENEPHOSPHONATE
Diseases
GWAS			Coffee consumption ( 21876539) Cognitive performance ( 20125193)
Protein-Protein Interactions		10 interactors: APLP1 CCDC90B LRIF1 NCALD RBM48 TFAM TFB2M TP53 UCHL5 ZHX1	8 interactors: ACTB C1QTNF2 CLTC DTX2 MEOX2 PNP TUBA4A TUBB
Entrez ID		4860	83988
HPRD ID		01247	09466
Ensembl ID			ENSG00000104490
Uniprot IDs		P00491	B2RB70 P61601
PDB IDs		1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA
Enriched GO Terms of Interacting Partners?		Transcription Initiation From Mitochondrial Promoter Transcription From Mitochondrial Promoter RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrion Organization Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Helicase Activity Cellular Response To Norepinephrine Stimulus Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Brain Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Head Development Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Response To Norepinephrine Mitochondrial DNA Repair DNA-templated Transcription, Initiation Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Metabolic Process Central Nervous System Development ER Overload Response	'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Inosine Catabolic Process NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Nicotinamide Riboside Catabolic Process Protein Polymerization Interleukin-2 Secretion Urate Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Platelet Activation Somite Specification Cellular Component Assembly Establishment Of Localization In Cell Interleukin-2 Production Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Immune System Process Protein Complex Assembly Cell Cycle Process Protein Heterotrimerization Urate Metabolic Process Protein Folding Purine Ribonucleoside Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Cellular Localization Cellular Protein Complex Assembly Segment Specification Positive Regulation Of Fatty Acid Oxidation
Tagcloud ?		adenylylimidodiphosphate altering amp analog anion anions atp channel cl closed conductance electrogenic flowed flux hidden hill lumen markov mv nonhydrolyzable pass rectification ruled sarcoplasmic sr substates unlikely voltage voltages	8q22 antiepileptic autistic disability dysmorphic encompassed epilepsy epileptic girl intellectual iq kuechler lips neurocalcin overlapping proposita q22 recognizable refined ribonucleotide rrm2b seizure sentences smallest spoke telecanthus vermilion walked word
Tagcloud (Difference) ?		adenylylimidodiphosphate altering amp analog anion anions atp channel cl closed conductance electrogenic flowed flux hidden hill lumen markov mv nonhydrolyzable pass rectification ruled sarcoplasmic sr substates unlikely voltage voltages	8q22 antiepileptic autistic disability dysmorphic encompassed epilepsy epileptic girl intellectual iq kuechler lips neurocalcin overlapping proposita q22 recognizable refined ribonucleotide rrm2b seizure sentences smallest spoke telecanthus vermilion walked word
Tagcloud (Intersection) ?