PNP and CCDC90B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNP	CCDC90B
Description		purine nucleoside phosphorylase	coiled-coil domain containing 90B
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Mitochondrion Membrane Mitochondrial Membrane
	Molecular Function	Nucleoside Binding Purine Nucleobase Binding Catalytic Activity Purine-nucleoside Phosphorylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Phosphate Ion Binding Identical Protein Binding Guanosine Phosphorylase Activity	Protein Binding
	Biological Process	Allantoin Metabolic Process Nucleobase-containing Compound Metabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Deoxyadenosine Catabolic Process Purine Ribonucleoside Salvage IMP Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response Nucleoside Metabolic Process Nucleotide Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Interleukin-2 Production Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Purine-containing Compound Salvage DAMP Catabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation
Pathways		Neutrophil degranulation Purine salvage Purine catabolism Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine Ribavirin ADME
Drugs		Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-deazainosine Guanosine Ribose-1-Phosphate (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium 3'-deoxyguanosine (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine Inosine 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE Forodesine
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Menopause (age at onset) ( 26414677)	Brain morphology (MOSTest) ( 32665545) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: APLP1 CCDC90B CEBPA CFTR LRIF1 NCALD NOS1AP RBM48 TFAM TFB2M TP53 UCHL5 ZHX1	32 interacting genes: AGR2 ANXA7 ARL15 BTBD2 CDKN2B CDKN2C DLEU1 DNM2 EIF2S2 FXYD6 GORASP2 KDM1A LAMTOR1 MOB2 NACA NIPSNAP3A PAFAH1B3 PCDHA4 PIN1 PNP PRDX5 PSMD11 RGL2 RNF10 SAT1 SDHAF2 SERPINB9 SMN1 TAC3 TK1 TNFAIP3 TSC22D1
Entrez ID		4860	60492
HPRD ID		01247	14378
Ensembl ID		ENSG00000198805	ENSG00000137500
Uniprot IDs		P00491	Q9GZT6
PDB IDs		1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA 5ETJ 5UGF 7ZSL 7ZSM 7ZSN 7ZSO 7ZSP	6H9M
Enriched GO Terms of Interacting Partners?		Mitochondrial Transcription Factor Activity Transcription Initiation At Mitochondrial Promoter Mitochondrial Transcription Nuclear Matrix RNA Metabolic Process Nucleic Acid Metabolic Process DNA-templated Transcription Negative Regulation Of Stem Cell Proliferation 14-3-3 Protein Binding Alpha-2B Adrenergic Receptor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Transcription Coactivator Binding Mitochondrial Nucleoid Mitochondrial RNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleobase-containing Compound Metabolic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Stem Cell Proliferation Regulation Of Stem Cell Proliferation Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Initiation Protein-containing Complex Protein Heterodimerization Activity Response To Vitamin B2 C/EBP Complex Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Mitochondrial Promoter Sequence-specific DNA Binding DNA-templated Transcription Initiation Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential RRNA (adenine-N6-)-methyltransferase Activity RRNA (adenine-N6,N6-)-dimethyltransferase Activity Cellular Response To Norepinephrine Stimulus
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