PNP and APLP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNP	APLP1
Gene Name		purine nucleoside phosphorylase	amyloid beta (A4) precursor-like protein 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytosol Cytoskeleton Extracellular Vesicular Exosome	Basement Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Drug Binding Phosphate Ion Binding	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Purine Nucleobase Metabolic Process Inosine Catabolic Process Purine Nucleotide Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Response To Drug Purine-containing Compound Salvage Small Molecule Metabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation Nucleobase-containing Small Molecule Metabolic Process Interleukin-2 Secretion	MRNA Polyadenylation Regulation Of Translation Endocytosis Apoptotic Process Cell Adhesion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Nervous System Development Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of CAMP Biosynthetic Process Forebrain Development Cellular Response To Norepinephrine Stimulus
Pathways		Purine catabolism Purine metabolism Metabolism of nucleotides Purine salvage
Drugs		Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-Deazainosine Guanosine Ribose-1-Phosphate 4\'-Deaza-1\'-Aza-2\'-Deoxy-1\'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol 3-Deoxyguanosine MT-Immucillin-H Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine 9-DEAZAINOSINE-2\',3\'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2\',3\'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2\',3\'-O-METHYLIDENEPHOSPHONATE
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APLP1 CCDC90B LRIF1 NCALD RBM48 TFAM TFB2M TP53 UCHL5 ZHX1	43 interactors: ANXA7 APBB1 APBB3 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24
Entrez ID		4860	333
HPRD ID		01247	00102
Ensembl ID			ENSG00000105290
Uniprot IDs		P00491	F5GZ08 P51693
PDB IDs		1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA	3PMR 3Q7G 3Q7L 3QMK
Enriched GO Terms of Interacting Partners?		Transcription Initiation From Mitochondrial Promoter Transcription From Mitochondrial Promoter RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrion Organization Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Helicase Activity Cellular Response To Norepinephrine Stimulus Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Brain Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Head Development Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Response To Norepinephrine Mitochondrial DNA Repair DNA-templated Transcription, Initiation Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Metabolic Process Central Nervous System Development ER Overload Response	Developmental Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Anatomical Structure Development Positive Regulation Of Protein Metabolic Process System Development Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Regulation Of Phosphorylation Response To Organic Substance Regulation Of Gene Expression Response To Copper Ion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Process Regulation Of Cell Proliferation Positive Regulation Of Protein Phosphorylation Cellular Aromatic Compound Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cell Death Regulation Of Kinase Activity Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Copper Ion Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Growth Response To Growth Factor Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Growth Positive Regulation Of Cell Death Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Response To Organic Cyclic Compound Digestive Tract Development Negative Regulation Of Cellular Metabolic Process Cell Cycle Arrest RNA Metabolic Process Response To Inorganic Substance Regulation Of Cell Cycle Digestive System Development Negative Regulation Of Cell Growth G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		adenylylimidodiphosphate altering amp analog anion anions atp channel cl closed conductance electrogenic flowed flux hidden hill lumen markov mv nonhydrolyzable pass rectification ruled sarcoplasmic sr substates unlikely voltage voltages	abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone
Tagcloud (Difference) ?		adenylylimidodiphosphate altering amp analog anion anions atp channel cl closed conductance electrogenic flowed flux hidden hill lumen markov mv nonhydrolyzable pass rectification ruled sarcoplasmic sr substates unlikely voltage voltages	abundance allocated analyzing aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing sv2 sv2a synaptic synaptogamin synaptophysin synaptotagmin vesicle zone
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