TFAM and TSPAN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFAM	TSPAN1
Description		transcription factor A, mitochondrial	tetraspanin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Protein-containing Complex Mitochondrial Nucleoid	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Mitochondrial Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Heat Shock Protein Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding	Protein Binding
	Biological Process	Response To Hypoxia Mitochondrial Transcription Transcription Initiation At Mitochondrial Promoter Response To Nutrient Mitochondrial Respiratory Chain Complex Assembly	Protein Stabilization
Pathways		Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 29403010) Height ( 23456168) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs ( 28235828) Mitochondrial heteroplasmy measurement ( 33731350) Refractive error ( 32231278)	Body mass index ( 26426971)
Interacting Genes		10 interacting genes: AGTRAP ARL6IP1 COL8A2 MGST3 PNP STATH TECR TFB1M TFB2M TSPAN1	4 interacting genes: MDK NFKBIB TFAM TMEM80
Entrez ID		7019	10103
HPRD ID		02702	18232
Ensembl ID		ENSG00000108064	ENSG00000117472
Uniprot IDs		E5KSU5 Q00059	O60635
PDB IDs		3FGH 3TMM 3TQ6 4NNU 4NOD 6ERP 6ERQ 6HB4 6HC3 7LBW 7LBX
Enriched GO Terms of Interacting Partners?		RRNA (adenine-N6,N6-)-dimethyltransferase Activity Mitochondrial Transcription Factor Activity Transcription Initiation At Mitochondrial Promoter RRNA Methylation RRNA Modification Mitochondrial RNA Metabolic Process Mitochondrial Nucleoid Collagen Type VIII Trimer Purine-nucleoside Phosphorylase Activity Purine Nucleobase Binding Urate Biosynthetic Process Nicotinamide Riboside Catabolic Process Nucleobase-containing Compound Biosynthetic Process Guanosine Phosphorylase Activity Inosine Catabolic Process Deoxyinosine Catabolic Process Extracellular Matrix Constituent, Lubricant Activity Very-long-chain Enoyl-CoA Reductase Activity DNA-templated Transcription Initiation RNA Methylation Small Molecule Biosynthetic Process Endoplasmic Reticulum Membrane Nucleoside Binding DAMP Catabolic Process Deoxyadenosine Catabolic Process Structural Constituent Of Tooth Enamel Hydroxyapatite Binding Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Macromolecule Methylation Angiotensin Type II Receptor Activity RRNA (adenine-N6-)-methyltransferase Activity Leukotriene-C4 Synthase Activity Purine Ribonucleoside Catabolic Process Purine Deoxyribonucleoside Metabolic Process IMP Catabolic Process Regulation Of Endoplasmic Reticulum Tubular Network Organization Deoxyribonucleoside Catabolic Process Pentosyltransferase Activity Saliva Secretion Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Formation RNA Modification Purine Ribonucleoside Salvage Purine Nucleoside Catabolic Process Methyltransferase Activity Allantoin Metabolic Process Endoplasmic Reticulum Tubular Network Membrane Organization Mitochondrial Transcription Urate Metabolic Process	Regulation Of Neutrophil Extravasation Chondroitin Sulfate Binding Positive Regulation Of Artery Morphogenesis Glial Cell Projection Elongation Defecation Positive Regulation Of Neutrophil Extravasation Cerebellar Granular Layer Development Leukocyte Chemotaxis Involved In Inflammatory Response Regulation Of Artery Morphogenesis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Blood Vessel Branching Negative Regulation Of Regulatory T Cell Differentiation Regulation Of Blood Vessel Branching Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Heparan Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Mitochondrial Transcription Mitochondrial Promoter Sequence-specific DNA Binding Mitochondrial Transcription Factor Activity Transcription Initiation At Mitochondrial Promoter Histone H3K36me2/H3K36me3 Demethylase Activity Histone H3K9 Demethylase Activity Histone H4K20me2 Reader Activity Histone H3K36 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity Estrous Cycle
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