HOPX and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HOPX	PTGER4
Description		HOP homeobox	prostaglandin E receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Histone Deacetylase Regulator Activity	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Trophectodermal Cell Differentiation Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Regulation Of Heart Contraction Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Negative Regulation Of Cell Differentiation Lung Alveolus Development Chaperone-mediated Protein Complex Assembly Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Gap Junction Assembly	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Prostanoid ligand receptors G alpha (s) signalling events
Drugs			Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS		Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic sclerosis ( 30247649)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		10 interacting genes: BUB1B EPC1 HDAC2 HOXB9 PICK1 PTGER4 SRF TCF12 TLX3 ZSCAN1	42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		84525	5734
HPRD ID		06280	03350
Ensembl ID		ENSG00000171476	ENSG00000171522
Uniprot IDs		Q9BPY8	A0PJF5 P35408
PDB IDs			5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Response To Dopamine Chromatin Sequence-specific Double-stranded DNA Binding Response To Oxygen Levels Eyelid Development In Camera-type Eye Long-term Synaptic Depression Response To Catecholamine Animal Organ Development Monoamine Transport Response To Amphetamine DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Transmission Response To Cocaine DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Response To Amine Norepinephrine Secretion Catechol O-methyltransferase Activity Cellular Response To Nutrient Levels Response To Alcohol Response To Hormone Developmental Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Negative Regulation Of Eosinophil Extravasation Serum Response Element Binding Cellular Developmental Process Negative Regulation Of Cellular Component Organization Response To Decreased Oxygen Levels Cellular Response To Phosphate Starvation Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Protein De-2-hydroxyisobutyrylase Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Eosinophil Migration Bronchus Cartilage Development Cis-regulatory Region Sequence-specific DNA Binding Lung Smooth Muscle Development Negative Regulation Of Locomotion Response To Alkaloid Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream	Heme Oxidation Heme Oxygenase (decyclizing) Activity
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