AP4B1

Description		adaptor related protein complex 4 subunit beta 1
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GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Membrane Coat AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane
	Molecular Function	Protein Binding Clathrin Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Localization To Somatodendritic Compartment
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Cerebral palsy
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729) Crohn's disease ( 28067908) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Novel Interacting Genes		2 novel interacting genes: BMP10 ZBTB14
Interacting Genes		4 interacting genes: AP4E1 BUB1 BUB1B ZNF576
Entrez ID		10717
HPRD ID		06259
Ensembl ID		ENSG00000134262
Uniprot IDs		A0AAQ5BGI8 B1ALD1 B1ALD3 B3KSJ4 B4DTG3 Q9Y6B7
PDB IDs		2MJ7
Enriched GO Terms of Interacting Partners?		Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinetochore Mitotic Checkpoint Complex Kidney Development AP-4 Adaptor Complex Cargo Adaptor Activity Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Sarcomere Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Negative Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sarcomere Organization Regulation Of Chromosome Organization Positive Regulation Of Sister Chromatid Cohesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cell Cycle Process Adult Heart Development Heart Trabecula Formation Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Regulation Of Organelle Organization Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Sister Chromatid Cohesion Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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