DDX54 and ZNF394

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DDX54	ZNF394
Name		DEAD-box helicase 54	zinc finger protein 394
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane	Nucleus
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Transcription Corepressor Activity RNA Binding RNA Helicase Activity Helicase Activity Signaling Receptor Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nuclear Estrogen Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RRNA Processing RNA Processing RNA Metabolic Process Estrogen Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		None	Generic Transcription Pathway
GWAS		Body mass index ( 26426971 ) Response to fenofibrate (adiponectin levels) ( 23149075 )	Age at first sexual intercourse ( 34211149 ) Facial emotion recognition (sad faces) ( 28608620 ) Smoking status (heavy vs never) ( 26423011 )
Interacting Genes		21 interacting genes: APP CASK CSNK2A1 DVL3 DYNLT1 ESR1 ESR2 NEDD4 NEDD4L NR3C1 PGR PJA1 POLR2G PTPRD RNF10 SEMA4A SMURF1 TMED9 USP7 YWHAE ZNF394	5 interacting genes: CCNDBP1 CLK2 DDX54 RNPS1 ZBTB47
Entrez ID		79039	84124
HPRD ID		13129	18333
Ensembl ID		ENSG00000123064	ENSG00000160908
Uniprot IDs		Q8TDD1	Q53GI3
PDB IDs		8FKT 8FKU 8FKV 8FKW 8FKX 8FKY	Not available
GO Terms Enriched among Interactors		Estrogen Response Element Binding Steroid Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Receptor Catabolic Process Nuclear Steroid Receptor Activity Positive Regulation Of Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Metabolic Process Protein Ubiquitination Enzyme Binding Nuclear Estrogen Receptor Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Toll-like Receptor Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Intracellular Signal Transduction Macromolecule Catabolic Process Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Synapse Organization Receptor Metabolic Process Regulation Of RNA Metabolic Process Protein Targeting To Vacuole Sodium Channel Inhibitor Activity Post-translational Protein Modification Protein Monoubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Metal Ion Transport Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity Establishment Of Protein Localization To Vacuole Regulation Of Dendrite Morphogenesis Signal Transduction Potassium Channel Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process	None