BUB3 and REXO4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		BUB3	REXO4
Description		BUB3 mitotic checkpoint protein	REX4 homolog, 3'-5' exonuclease
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Nucleus Nucleoplasm Nucleolus Nuclear Speck
	Molecular Function	Protein Binding Ubiquitin Binding	Nucleic Acid Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity
	Biological Process	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Chromosome Segregation	DNA Metabolic Process DNA Repair DNA Catabolic Process Regulation Of DNA-templated Transcription RRNA Processing RNA Processing
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Left-handedness ( 32989287) Lung volume ( 34128465) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)	ABO blood group (A vs O) ( 34202464) ABO blood group (AB vs non-AB) ( 34202464) ABO blood group (AB vs O) ( 34202464) ABO blood group (B vs non-B) ( 34202464) ABO blood group (B vs O) ( 34202464) ABO blood group (O vs non-O) ( 34202464) Malaria ( 31844061) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		20 interacting genes: ANXA1 BUB1 BUB1B CEBPA CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 REXO4 RPL37A SUGT1 THRA TOP1 UBA1 WBP4	5 interacting genes: BUB3 ESR1 ESR2 HSF2BP OGT
Entrez ID		9184	57109
HPRD ID		04761	04239
Ensembl ID		ENSG00000154473	ENSG00000148300
Uniprot IDs		A0A140VJF3 O43684	B4DJ95 B4E331 Q9GZR2
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway NAD+-protein-serine ADP-ribosyltransferase Activity Nucleus NuRD Complex DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Sin3-type Complex Protein Lysine Delactylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Specification Fungiform Papilla Formation Chromatin Remodeling Meiotic Sister Chromatid Cohesion, Centromeric NF-kappaB Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromatin Binding Hair Follicle Placode Formation Histone Deacetylase Binding Histone Deacetylase Complex Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Fate Commitment Regulation Of Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Response To Temperature Stimulus Chromatin Organization Chromosome Organization Positive Regulation Of Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Protein Auto-ADP-ribosylation Positive Regulation Of Developmental Process Meiotic Sister Chromatid Cohesion Cytosol NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Stem Cell Population Maintenance Response To Steroid Hormone NAD+-protein-aspartate ADP-ribosyltransferase Activity Protein Lysine Deacetylase Activity Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Stem Cell Differentiation Eyelid Development In Camera-type Eye Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides	Nuclear Estrogen Receptor Activity Estrogen Response Element Binding Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Cellular Response To Estradiol Stimulus Lipid Binding Nuclear Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Bub1-bub3 Complex Response To Estradiol Protein Localization To Chromosome Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Organelle Intracellular Signal Transduction Nucleoplasm Hormone-mediated Signaling Pathway Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Protein O-acetylglucosaminyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Mitotic Checkpoint Complex Cellular Response To Oxygen-containing Compound Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Carbon Catabolite Regulation Of Transcription Female Meiosis I Rhythmic Process Nitric-oxide Synthase Regulator Activity Regulation Of Transcription By Glucose Transcription By RNA Polymerase II Prostate Gland Growth Vagina Development Double-strand Break Repair Involved In Meiotic Recombination NSL Complex
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