RDH12

Description		retinol dehydrogenase 12
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Photoreceptor Inner Segment Membrane
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity All-trans-retinol Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Retinol Metabolic Process Photoreceptor Cell Maintenance Cellular Detoxification Of Aldehyde
Pathways		The canonical retinoid cycle in rods (twilight vision) Defective visual phototransduction due to RDH12 loss of function
Drugs		Vitamin A
Diseases		Leber congenital amaurosis (LCR)
GWAS
Novel Interacting Genes		1 novel interacting genes: ADCY2
Interacting Genes		6 interacting genes: ANXA8L1 BUB1 CFTR MAP1LC3A PLEKHA7 RBPMS
Entrez ID		145226
HPRD ID		10585
Ensembl ID		ENSG00000139988
Uniprot IDs		A0A0S2Z613 Q96NR8
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Forskolin Cellular Response To Forskolin SMAD Protein Signal Transduction Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Zonula Adherens Maintenance Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Enamel Mineralization MRNA CDS Binding Cellular Response To Oxygen-glucose Deprivation Cellular Response To Oxygen-containing Compound Response To Ketone Intracellular Signal Transduction Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Sister Chromatid Cohesion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Response To Iron(II) Ion Cellular Response To Nitrogen Starvation Zonula Adherens Adherens Junction Maintenance Delta-catenin Binding CAMP Biosynthetic Process Adenylate Cyclase Activity Meiotic Sister Chromatid Cohesion Response To Oxygen-glucose Deprivation Response To Alcohol Adenylate Cyclase Binding Pre-mRNA Intronic Binding Autolysosome Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Pore Complex Golgi-associated Vesicle Membrane Phosphatidylethanolamine Binding
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