RDH12 and ANXA8L1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RDH12	ANXA8L1
Description		retinol dehydrogenase 12	annexin A8 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Photoreceptor Inner Segment Membrane	Cytoplasm Vesicle Membrane Sarcolemma
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity All-trans-retinol Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity	Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Retinol Metabolic Process Photoreceptor Cell Maintenance Cellular Detoxification Of Aldehyde	Endosome Organization Endosomal Transport
Pathways		The canonical retinoid cycle in rods (twilight vision) Defective visual phototransduction due to RDH12 loss of function
Drugs		Vitamin A
Diseases		Leber congenital amaurosis (LCR)
GWAS
Interacting Genes		6 interacting genes: ANXA8L1 BUB1 CFTR MAP1LC3A PLEKHA7 RBPMS	6 interacting genes: ACD RDH12 TERF1 TERF2IP TINF2 UCHL5
Entrez ID		145226	728113
HPRD ID		10585	19373
Ensembl ID		ENSG00000139988	ENSG00000264230
Uniprot IDs		A0A0S2Z613 Q96NR8	B4DTF2 P13928 Q5VT79
PDB IDs			1W3W 1W45
Enriched GO Terms of Interacting Partners?		Response To Forskolin Cellular Response To Forskolin SMAD Protein Signal Transduction Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Zonula Adherens Maintenance Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Enamel Mineralization MRNA CDS Binding Cellular Response To Oxygen-glucose Deprivation Cellular Response To Oxygen-containing Compound Response To Ketone Intracellular Signal Transduction Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Sister Chromatid Cohesion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Response To Iron(II) Ion Cellular Response To Nitrogen Starvation Zonula Adherens Adherens Junction Maintenance Delta-catenin Binding CAMP Biosynthetic Process Adenylate Cyclase Activity Meiotic Sister Chromatid Cohesion Response To Oxygen-glucose Deprivation Response To Alcohol Adenylate Cyclase Binding Pre-mRNA Intronic Binding Autolysosome Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Pore Complex Golgi-associated Vesicle Membrane Phosphatidylethanolamine Binding	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Positive Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Protection From Non-homologous End Joining At Telomere Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Nuclear Body Telomere Maintenance In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Organelle Organization Regulation Of Cellular Component Organization Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromosome Negative Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process DNA Damage Response
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