ZEB1 and DRAP1

Number of citations of the paper that reports this interaction (PMID 9418848)
14

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ZEB1	DRAP1
Gene Name		zinc finger E-box binding homeobox 1	DR1-associated protein 1 (negative cofactor 2 alpha)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding E-box Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Pattern Specification Process Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Response To Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Forebrain Development Response To Nutrient Levels Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Cellular Response To Amino Acid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cochlea Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways			Signaling by Activin Signaling by NODAL
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)
Protein-Protein Interactions		11 interactors: ATM CDK6 CTBP1 CTBP2 DRAP1 EP300 KAT5 SMAD2 SMAD3 SMAD7 USP7	22 interactors: APP ARHGEF10L CDKN2C DNAJB11 DR1 FEZ1 FEZ2 FOXH1 GTF2B LMO2 NCK2 NFYB PIK3R3 POLE3 SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1
Entrez ID		6935	10589
HPRD ID		01798	03796
Ensembl ID		ENSG00000148516	ENSG00000175550
Uniprot IDs		B2RBI8 P37275	Q14919
PDB IDs		2E19	1JFI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Histone Modification RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Primary MiRNA Processing Epithelium Development Regulation Of Metabolic Process Anterior/posterior Pattern Specification Regulation Of Binding Chromatin Modification Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Somitogenesis Regulation Of Cellular Protein Metabolic Process Paraxial Mesoderm Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Somite Development Protein Stabilization Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Protein Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Segmentation Ureteric Bud Development	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Viral Process Histone Acetylation Regulation Of Receptor Activity Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Internal Protein Amino Acid Acetylation Response To Organic Substance Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Acetylation Negative Regulation Of Transcription, DNA-templated Regulation Of Epidermal Growth Factor-activated Receptor Activity
Tagcloud ?		cataract cataracts converge cooperate emt hedgehog heterozygous highlight ionizing irradiated lens mesenchymal nanog neonatally patched pluripotent progenitors property ptch1 radiation shh smad sonic stemness transforming traumatic undergo unrelated vim
Tagcloud (Difference) ?		cataract cataracts converge cooperate emt hedgehog heterozygous highlight ionizing irradiated lens mesenchymal nanog neonatally patched pluripotent progenitors property ptch1 radiation shh smad sonic stemness transforming traumatic undergo unrelated vim
Tagcloud (Intersection) ?