ZEB1 and TRIM26

Number of citations of the paper that reports this interaction (PubMedID 33649471)
43

Data Source:
BioGRID (pull down)

		ZEB1	TRIM26
Description		zinc finger E-box binding homeobox 1	tripartite motif containing 26
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding E-box Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Cell Population Proliferation Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Keratinocyte Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of T Cell Differentiation In Thymus Keratinocyte Proliferation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Embryonic Camera-type Eye Morphogenesis Embryonic Morphogenesis Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Cellular Response To Amino Acid Stimulus Cochlea Morphogenesis	Immune System Process Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Suppression Of Symbiont Invasion Protein K11-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Interleukin-4 and Interleukin-13 signaling Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Interferon gamma signaling
Drugs
Diseases		Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy Posterior polymorphous corneal dystrophy (PPCD)
GWAS		Pulse pressure ( 28135244) Uterine fibroids ( 31649266) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) General cognitive ability ( 29844566) Hematocrit ( 32888494) LDL cholesterol levels ( 32203549) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 22883433 30285260 21926974) Squamous cell lung carcinoma ( 28604730) Triglyceride levels ( 32203549) Waist-hip index ( 34021172)
Interacting Genes		12 interacting genes: ATM CDK6 CTBP1 CTBP2 DRAP1 EP300 KAT5 SMAD2 SMAD3 SMAD7 TRIM26 USP22	32 interacting genes: BEND7 BIVM CEBPD CTNNB1 DDX41 EPN2 EPN3 INCA1 IRF3 LMNA MACROH2A1 MAGEA6 MECOM MIR138-2 MIR18B MNAT1 OTUB2 PHF7 RABEP1 RNF126 SOX2 SUMO2 TAB1 THAP1 TLE5 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 USP5 ZEB1
Entrez ID		6935	7726
HPRD ID		01798	02901
Ensembl ID		ENSG00000148516	ENSG00000234127
Uniprot IDs		B2RBI8 B4DGU2 P37275	A0A024RCP3 Q12899
PDB IDs		2E19
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H4 Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process I-SMAD Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Positive Regulation Of Cell Adhesion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Peptide Lactyltransferase (CoA-dependent) Activity Paraxial Mesoderm Morphogenesis Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Transcription Coregulator Binding Negative Regulation Of Ossification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Growth Somitogenesis Anterior/posterior Pattern Specification Negative Regulation Of Cell Differentiation	Negative Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process CGAS/STING Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Epithelial Cell Differentiation Clathrin Vesicle Coat Regulation Of RNA Metabolic Process Protein Monoubiquitination Protein Polyubiquitination Regulation Of Epithelial Cell Differentiation Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Ubiquitin Protein Ligase Activity Regulation Of Sister Chromatid Cohesion Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Type I Interferon Production Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of Cell Communication
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