ZEB1 and USP22

Number of citations of the paper that reports this interaction (PubMedID 36906615)
61

Data Source:
BioGRID (pull down)

		ZEB1	USP22
Description		zinc finger E-box binding homeobox 1	ubiquitin specific peptidase 22
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding E-box Binding	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Cell Population Proliferation Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Keratinocyte Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of T Cell Differentiation In Thymus Keratinocyte Proliferation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Embryonic Camera-type Eye Morphogenesis Embryonic Morphogenesis Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Cellular Response To Amino Acid Stimulus Cochlea Morphogenesis	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle
Pathways		Interleukin-4 and Interleukin-13 signaling Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases		Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy Posterior polymorphous corneal dystrophy (PPCD)
GWAS		Pulse pressure ( 28135244) Uterine fibroids ( 31649266) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		12 interacting genes: ATM CDK6 CTBP1 CTBP2 DRAP1 EP300 KAT5 SMAD2 SMAD3 SMAD7 TRIM26 USP22	17 interacting genes: BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1
Entrez ID		6935	23326
HPRD ID		01798	19411
Ensembl ID		ENSG00000148516	ENSG00000124422
Uniprot IDs		B2RBI8 B4DGU2 P37275	Q9UPT9
PDB IDs		2E19
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H4 Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process I-SMAD Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Positive Regulation Of Cell Adhesion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Peptide Lactyltransferase (CoA-dependent) Activity Paraxial Mesoderm Morphogenesis Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Transcription Coregulator Binding Negative Regulation Of Ossification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Growth Somitogenesis Anterior/posterior Pattern Specification Negative Regulation Of Cell Differentiation	Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome
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