TBX15 and POLE2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TBX15	POLE2
Gene Name		T-box 15	polymerase (DNA directed), epsilon 2, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Tle3-Aes Complex	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity	DNA Binding DNA-directed DNA Polymerase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Embryonic Cranial Skeleton Morphogenesis	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis
Pathways			Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS		Congenital heart malformation ( 23708190) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		3 interactors: ATXN1 POLE2 VENTX	13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27
Entrez ID		6913	5427
HPRD ID		16035	16007
Ensembl ID		ENSG00000092607	ENSG00000100479
Uniprot IDs		Q8N8P2 Q96SF7	P56282
PDB IDs			2V6Z
Enriched GO Terms of Interacting Partners?		Error-prone Translesion Synthesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Translesion Synthesis Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Mitotic Recombination Telomere Maintenance Via Telomere Lengthening DNA Replication Initiation	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression
Tagcloud ?			algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated
Tagcloud (Difference) ?			algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated
Tagcloud (Intersection) ?