POLE2 and DRD3

		POLE2	DRD3
Description		DNA polymerase epsilon 2, accessory subunit	dopamine receptor D3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen	Plasma Membrane Membrane Synapse
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Internalization Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Visual Learning Response To Xenobiotic Stimulus Regulation Of Dopamine Secretion Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Response To Cocaine Dopamine Metabolic Process Regulation Of Potassium Ion Transport Response To Morphine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonate Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Secretion By Cell
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Dopamine receptors G alpha (i) signalling events
Drugs		Cladribine	Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Haloperidol Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Norclozapine Cariprazine Mianserin Asenapine Amisulpride Sarizotan Sumanirole Nandrolone decanoate Captodiame AS-8112 Blonanserin Pipamperone Tianeptine Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Piribedil Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Trigger finger ( 32740585)	Chronotype ( 30696823) Feeling hurt ( 29500382) Personality dimensions ( 23903073) Smooth-surface caries ( 24556642)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620	16 interacting genes: CLIC6 DRD1 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX RGS9
Entrez ID		5427	1814
HPRD ID		16007	00540
Ensembl ID		ENSG00000100479	ENSG00000151577
Uniprot IDs		P56282	A1A4V4 A8K8E4 E9PCM4 P35462 X5D2G4
PDB IDs		2V6Z 5VBN 7PFO 7PLO	3PBL 7CMU 7CMV 8IRT 9F33 9F34
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization	Cell Cortex Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeletal Protein Binding G Protein-coupled Dopamine Receptor Signaling Pathway Actin Binding D2 Dopamine Receptor Binding Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Localization Vesicle Membrane Presynaptic Modulation Of Chemical Synaptic Transmission Cortical Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cadherin Binding Plasma Membrane Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Neuron Migration Cytoplasm Translation Elongation Factor Activity Regulation Of Actin Filament Organization Actomyosin Structure Organization Glutamatergic Synapse Regulation Of Protein Localization Negative Regulation Of Protein Catabolic Process Regulation Of Actin Filament Polymerization Spectrin Binding Cortical Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Intracellular Transport Regulation Of Metal Ion Transport Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Response To Amphetamine Regulation Of Actin Filament Length Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Periphery COP9 Signalosome Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Transport Regulation Of Monoatomic Ion Transport Extracellular Exosome Structural Molecule Activity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Dendritic Shaft Positive Regulation Of Cytoskeleton Organization
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