POLE2 and SAV1

		POLE2	SAV1
Description		DNA polymerase epsilon 2, accessory subunit	salvador family WW domain containing protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Transcription Regulator Activator Activity
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis	Hair Follicle Development Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Keratinocyte Differentiation Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Keratinocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Stem Cell Population Maintenance
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Signaling by Hippo
Drugs		Cladribine
Diseases
GWAS		Trigger finger ( 32740585)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620	4 interacting genes: EP300 NEDD4 STK3 STK4
Entrez ID		5427	60485
HPRD ID		16007	06229
Ensembl ID		ENSG00000100479	ENSG00000151748
Uniprot IDs		P56282	B3KTQ1 Q9H4B6
PDB IDs		2V6Z 5VBN 7PFO 7PLO	6AO5
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization	Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Canonical Wnt Signaling Pathway Neural Tube Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Organelle Hepatocyte Apoptotic Process Hemopoiesis Positive Regulation Of Hippo Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Embryonic Epithelial Tube Formation Hippo Signaling Protein Stabilization Wnt Signaling Pathway Epithelial Tube Formation Negative Regulation Of Organ Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Regulation Of Hippo Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Epithelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organ Growth Positive Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Protein Stability Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Fat Cell Differentiation Protein Serine/threonine Kinase Activator Activity Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Protein Transport Formation Of Structure Involved In A Symbiotic Process Protein Tetramerization Positive Regulation Of Hepatocyte Apoptotic Process
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